In diseases like leukemia, a kind of cancer, the bone marrow
produces abnormal blood cells.
Not exact matches
Healthy plasma
cells produce antibodies that fight infection in the body, but myeloma
cells produce high levels of
abnormal antibodies that, when the cancer
cells accumulate, they crowd out production of other important
blood cells, both red and white.
Multiple myeloma is preceded by a
blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which
abnormal plasma
cells produce many copies of an antibody protein.
This caused atypical growth of
blood - forming stem
cells that were more likely to
produce the
abnormal B
cells most common in B - ALL.
In sickle
cell disease, individuals have two copies of a genetic mutation that
produces an
abnormal change in hemoglobin, the primary molecule that carries oxygen in the
blood.
Instead of
producing healthy lymphocytes, white
blood cells that fight infections, his bone marrow was unleashing
abnormal lymphocytes into his bloodstream.
Each MPN is a different condition, but they are thought to be caused by an
abnormal cancer stem
cell that may have acquired genetic mutations that make it unable to
produce blood cells normally
And according to recent studies conducted in Japan, the full ripe bananas with dark patches on their skin
produce the largest quantity of TNF (Tumor Necrosis Factor), a cytokine that fights
abnormal tumor
cells in the body by stimulating the production of white
blood cells and assisting their communication.
Essentially, the aim is to genetically alter patients» own
blood stem
cells so they don't
produce abnormal hemoglobin.
When white
blood cells multiply in an
abnormal and uncontrolled way, these immature
cells take over, literally crowding the bone marrow thereby preventing it from
producing healthy
blood cells and causing a shortage of red
blood cells.
This means that
abnormal blood cells can be
produced or that production of normal
cells can be halted due to an action of chloramphenicol on patient bone marrow.