Sentences with phrase «producing cells»

Despite the reduced levels of insulin released after arsenic exposure, however, the researchers found no significant differences in inflammation of the pancreas or the number of insulin - producing cells (beta cells) in the pancreas that are known to promote the development of diabetes.

Forbes, Robert Langreth, February 20, 2008: In progress toward a stem - cell treatment for diabetes, researchers at a small San Diego biotech company have devised a procedure for turning human embryonic stems cells into insulin - producing cells inside mice.

Melanoma is a form of cancer that develops from the pigment producing cells of the skin.

Renowned for our work in beta cell production and research, we are conducting studies to expand and boost insulin - producing cells and make them less susceptible to attack by the immune system.

It is an autoimmune disease caused by cells of the immune system mistakenly attacking and destroying the insulin - producing cells of the pancreas.

Although CD144 - or CD31 - producing cells were seen as early as 3 days in vitro (not shown), a homogeneous monolayer of CD144 and CD - 31 expressing cells was seen by 8 to 10 days of exposure to high density culture conditions (Figure 1F — 1H).

Novocell has developed and proven methods to efficiently generate pancreatic, insulin - producing cells from hESCs, demonstrating for the first time that hESCs could serve as a source of cellular therapy for diabetes.

Moreover, the award will fund a tissue regeneration program that helps to identify biological factors that either contribute to or help prevent against damage that diabetes causes to the body's insulin - producing cells, eyes, kidneys and cardiovascular system.

Previous studies demonstrated the VASA expression to increase with germ cell differentiation from mouse and human ES cells by co-culturing with BMP4 - producing cells [57] and the addition of recombinant human BMP4 [6], respectively.

Chong Wee Liew, Ph.D., lead author and a postdoctoral researcher in the Kulkarni lab, first examined the expression of the tribbles protein in pancreatic islets (which house beta cells and other hormone - producing cells) in both humans and mice.

ViaCyte grows replacement insulin - producing cells from human embryonic stem cells, which are placed in a semipermeable pouch.

Thomson still supports lifting Bush's restrictions, he said, because no one knows whether the new iPS cells can match embryonic cells» knack for growing into any kind of tissue — brain cells, heart muscle, insulin - producing cells and dozens of others — in mass quantities.

Human skin cells have also been directly converted into neurons that can be used to study and find treatments for diseases in the brain, as well as liver cells and insulin - producing cells of the pancreas.

Biologists often view cancer primarily as a genetic program gone wrong, with mutations and epigenetic changes producing cells that don't behave the way they should: Genes associated with cell division and growth may be turned up, and genes for programmed cell death may be turned down.

Our findings fill an important gap in our understanding of how the fat body transmits nutritional information to the insulin producing cells to control body size.

The insulin - producing cells were immunostained using an anti-ILP2 antibody and an anti-ILP5 antibody.

Testicular tissue exposed to painkillers in a culture dish had around a quarter fewer sperm - producing cells after exposure to paracetamol or ibuprofen.

(E, F) Overexpressing either GBP1 or GBP2 reduces ILP2 (E) and ILP5 (F) accumulation in the insulin - producing cells.

Nevertheless, our data suggest that GBP2 is the major signaling molecule produced in the fat body that regulates ILP secretion from the insulin - producing cells, with GBP1 playing a secondary role.

Novocell is developing an alternative to insulin injections by producing cells that will secrete insulin in patients similar to the cells that were lost.

To confirm whether ILP accumulation in the insulin - producing cells actually results in a decrease of ILP2 concentration in the circulating hemolymph, we collected hemolymph from wild - type, and gbp1, gbp2 ex67 heterozygous and homozygous mutant larvae at 24 h AL3E, and performed western blot analyses using an anti-ILP2 antibody.

Our data does not allow us to distinguish whether they act on the insulin - producing cells themselves or on other cells in the brain to regulate ILP secretion.

(I, J) Overexpressing GBP1 or GBP2 at two different temperatures shows reduced densities of ILP2 (I) and ILP5 (J) signals in the insulin - producing cells.

We also found that both ILP2 and ILP5 accumulated in the insulin - producing cells of gbp1, gbp2 null mutant larvae when compared to wild - type or heterozygous mutant animals (Fig 4E — 4H).

They were then transplanted into mice where they developed further into insulin - producing cells, curing the mice of type 1 diabetes.

These results indicate an involvement of GBP1 and GBP2 in ILP secretion from the insulin - producing cells, which would result in a decrease of IIS activity in the entire body.

When TOR signaling is reduced in the fat body, the insulin - producing cells do not secrete ILPs.

(C, D) Culturing wild - type brains with conditioned media from GBP1 and GBP2 expressing cells decreases the densities of ILP2 (C) and ILP5 (D) signals in the insulin - producing cells.

Researchers are developing a smartphone - controlled system that can trigger insulin - producing cells implanted in the body.

(A, B) Culturing wild - type brains with conditioned media from GBP1 and GBP2 expressing cells induces low level of ILP2 (A) and ILP5 (B) accumulation in the insulin - producing cells.

In addition, we found that GBPs stimulate ILP secretion from the insulin - producing cells, either directly or indirectly, thereby increasing insulin and insulin - like growth factor signaling activity throughout the body.

Furthermore, these peptides control ILP secretion from the insulin - producing cells, which alters IIS activity in the entire body.

Based on a number of studies, we postulate that to transmit nutritional information from the fat body to the insulin - producing cells, the fat - body — derived signal would need to have the following properties: (1) it should be produced in the fat body and secreted into the hemolymph, (2) its expression and / or secretion should be amino acid - and TOR - sensitive, (3) it should act downstream of TOR signaling to stimulate ILP secretion from the insulin - producing cells, and (4) its secretion should increase IIS activity in the entire body, resulting in increased body size.

(E, F) Overexpressing both GBP1 and GBP2 reduces ILP2 (E) and ILP5 (F) accumulation in the insulin - producing cells of gbp1, gbp2 ex67 mutant larvae.

In fact, Unpaired 2 and CCHamide - 2 produced in the fat body regulate ILP secretion from the insulin - producing cells, although their expression is regulated by carbohydrates and lipids instead of amino acids [14,15].

In fact, they had managed to recruit other Wnt1 - producing cells from the surrounding tissue to restore the biclonality needed for growth.

(G, H) Overexpressing GBP1 or GBP2 reduces the densities of ILP2 (G) and ILP5 (H) signals in the insulin - producing cells.

Since we know the Gal4 - UAS system is sensitive to temperature and in fact, expression levels of these transgenes differ at 22 °C and 25 °C, Drosophila GBPs might also suppress ILP secretion from the insulin - producing cells when expressed at high concentrations.

ViaCyte is engineering the Encaptra ® cell delivery system to enable implanted PEC - 01 ™ cells to survive and thrive in vivo and to differentiate into functional insulin - producing cells.

In an attempt to bring patient - specific induced pluripotent stem cell (iPSCs) technology closer to the clinic, researchers have created iPSCs from patient - derived chondrocytes, using an non-integrative reprogramming method, and used these to then create large numbers of cartilage producing cells.

Such cells exhibit properties characteristic of functional human adult pancreatic insulin producing cells and provide protection in an animal model of diabetes characterized by loss of pancreatic insulin producing cells.

In a study published Wednesday in the journal Science Translational Medicine, Chinese researchers detail a process by which a dedicated smartphone app is used to «switch on» engineered insulin - producing cells in mice.

(E, F) Co-culturing wild - type brains with fat bodies from wild - type, but not from gbp1, gbp2 ex67, larvae induces low levels of ILP2 (E) and ILP5 (F) accumulation in the insulin - producing cells.

For instance, very small concentrations of GBPs might either directly or indirectly act on the insulin - producing cells to regulate ilp2 mRNA expression and peripheral tissues to regulate AKT expression.

This signal regulates systemic growth by controlling the synthesis and secretion of insulin - like peptides (ILPs) by the insulin - producing cells of the brain [10].

Although Unpaired 2 and CCHamide - 2 stimulate ILP secretion from the insulin - producing cells, their secretions are not sensitive to amino acids.

However, to transmit nutritional information from the fat body to the insulin - producing cells, we proposed that the fat - body — derived signal would need to be sensitive to both the amino acid concentration of the larval food and to TOR signaling in the fat body.

This suggests that other factors produced in the fat body control ILP secretion from the insulin - producing cells.

Novocell was the first to demonstrate that implantation of hES - derived pancreatic cells into mice results in the generation of glucose - responsive insulin producing cells.

IL - 17 — producing cells can be found in gut biopsy samples of patients with acute GVHD (6).