Sentences with phrase «producing cells of the immune system»

They fused mouse B cells — antibody - producing cells of the immune system — with human myeloma (also known as B cell cancer) cell lines in a new technique called hybridoma technology.

One of the functions of bone marrow is to produce the cells of the immune system that fight off infection.

Not exact matches

This type of diabetes strikes in the early teenage years and begins with the immune system destroying the cells in the pancreas that produce insulin, according to Patrick Holford, founder of the Institute for Optimum Nutrition in London.

Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin - producing (islet, or islets of Langerhans) cells in the pancreas.

Researchers are developing many different versions of CAR - T cell therapies, but the basic premise is the same: Doctors remove a patient's T cells (immune system cells that attack invaders) from a blood sample and genetically modify them to produce artificial proteins on their surfaces.

The four children also had more of the types of species that are known to trigger gut inflammation, a possible prelude to type - 1 diabetes, in which the body's immune system mistakenly produces antibodies that attack and destroy the beta cells of the pancreas that normally make insulin.

By studying infected cells grown in a laboratory, the team found that a large number of CMV's genes help it hide from the immune system by allowing it to destroy many of the proteins produced by the body during virus infection and preventing them from activating immune cells to destroy the virus.

The viruses also exploit an enzyme that cells use to destroy RNA to instead produce short stretches of RNA that, among other things, may help the virus avoid the immune system of its host.

But roundworms seem to shift the balance of the immune system towards producing more type 2 T cells.

On encountering the TB bacillus, receptors on immune - system scavenger cells known as macrophages stimulate the conversion of circulating vitamin D to its active form, which produces a peptide that destroys the bacillus.

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

This made it possible for their immune systems to produce sufficient amounts of CD8 T cells that were primed to attack and kill HIV - infected cells.

The new study revives suspicions that adenoviruses cause an immune «own goal», priming people's immune systems to produce CD4 cells — the very cells that HIV prefers to infect — and, worse still, to direct those cells to the parts of the body that are most vulnerable to the virus during sex.

University of Alabama at Birmingham researchers have now shown that activated T - cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

By combining multiple images, the researchers produced movies correlating the production of hydrogen peroxide to the activities of the immune system cells.

These are specialized immune cells that produce antibodies to fight milk proteins as part of the immune system.

Rick Maizels at the University of Edinburgh and his colleagues find that the worms manipulate their hosts into producing cells called regulatory T cells, which calm the immune system.

Loss of insulin - producing beta cells has long been recognized as a cause of Type 1 diabetes, in which the immune system mistakenly attacks and destroys beta cells.

In type 1 diabetes, the immune system attacks and destroys insulin - producing cells in the islets of the pancreas.

The findings, published today in Nature, demonstrate that these myeloproliferative neoplasias only appear after damage to the microenvironment that sustains and controls the hematopoietic stem cells — the cells that produce the cells of the blood and the immune system.

It also interferes with CD8 T cells ability to produce cytokines, chemical messengers that recruit other arms of the immune system.

In the tea drinkers» immune systems, gamma delta T cells produced five times more infection - fighting interferon when exposed to disease - causing bacteria than did the T cells of the coffee drinkers.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

The immune system maintains a rich abundance of «natural killer» cells to confront microbial invaders, but as the body gains the upper hand in various infections it sometimes starts to produce even more of the cells.

When susceptible people come into contact with flakes of cat skin called dander, T cells in their immune systems set off a chemical chain reaction that produces the familiar symptoms of allergy, including sneezing, runny noses, itching and asthma.

These would act as a substitute for the insulin - producing cells that are destroyed by the immune systems of people with type 1 diabetes.

The scientists at Leiden University Medical Center (LUMC) have shown that immune system cells, which react to gluten, produce chemicals called cytokines that can contribute to the development of a rare form of lymphoma (cancer of the white blood cells).

Like the childhood form, the insulin - producing beta cells of the pancreas are destroyed by the body's own immune system.

In healthy individuals, immune cells produce proteins called antibodies that attack foreign invaders to destroy them and clear them out of the system.

So - called induced pluripotent stem (iPS) cells, which are derived from adult human tissue, have the added advantage of producing tissues and organs genetically matched to a recipient, avoiding the problem of immune system rejection.

Vaccines work by exposing the body to the disease - causing agent or a fragment of it, which primes the immune system to produce a flood of antibodies that stick to the infecting organism and block it from entering cells.

For example, scientists could engineer T cells, sentinels of the immune system, with genetic circuits that initiate a response to wipe out tumors when they detect the presence of two or three «biomarkers» produced by cancer cells, Lu says.

* In type 1 diabetes, the insulin - producing cells in the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cells).

Nevertheless, Hahm adds, it appears that «these cells are producing high amounts of suPAR, which becomes the mediator that communicates between the immune system and the kidney.

The researchers found that the mice responded to the parasite by shifting their immune system into high gear, producing large numbers of white blood cells.

Consistent with other studies, they found that as early as 13 weeks of development, the fetus was producing a range of immune system cells, including dendritic cells, which recognize invaders and signal other immune cells to attack.

And on page 1693, another team reports further evidence of the action of natural selection in people: A gene expressed in microglia, immune cells of the nervous system, produces a protein found only in humans.

Because bone marrow produces immune cells, the procedure led to a brief period in which the recipient's immune system blended with that of the donor.

Shortly after infection, HIV levels skyrocket, but then the immune system and other antiviral factors produced by cells drive down the amount of virus in the blood — the so - called viral load — and establish a «set point.»

A high level of diversification occurs naturally in the B cells of the immune system, which produce antibodies.

Such genes might include those for various cytokines — substances produced by cells of the immune system — such as tumour necrosis factor, interleukins and interferons.

Researchers can grow these lymphocytes in the laboratory with the help of substances, such as interleukin 2, that are produced by cells of the immune system.

helper T cells (CD4)- a group of T cells that help produce antibodies, activate killer T cells (CD8), and make sure the immune system works smoothly.

Researchers from Aarhus University conducted a case - control study on the condition of the dopamine - producing nerve cells in the brain and cells that participate in the brain's immune system in people suffering from rapid eye movement sleep behaviour disorder (RBD).

The generation of these T cell subsets depends on the action of cytokines such as IL - 6, IL - 12 and IL - 23, produced mostly by cells of the innate immune system.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.

Existing vaccination methods depend on stimulating the body's immune system, so that white blood cells produce antibodies that attach to the surface of the virus and start the process of killing it.

Some not - yet - identified molecule, or combination of molecules, such as proteins, fats, or sugars, made by bacteria cause the immune system to produce T helper 17 cells (Th17), which trigger a surge in inflammation as part of the response to a pathogenic strain.

In the May 11, 2015 issue of Nature, researchers from the University of Chicago show how these tumors shield themselves from T cells — the immune system's front - line anti-cancer weapon — by producing high levels of beta - catenin, an intracellular messenger.

Kraig and his team, which includes Aya Pusic and Kae Pusic, PhD, discovered that dendritic cells, professional antigen presenting cells of the immune system, can be stimulated by factors released during environmental enrichment to produce exosomes containing microRNAs that improve brain health.