Sentences with phrase «producing cells of the pancreas»

It is often caused by the destruction of the insulin - producing cells of the pancreas resulting in an insulin deficiency.

The overproduction could attack the insulin - producing cells of the pancreas and trigger diabetes, she wrote in the June 6 Journal of Proteome Research of the American Chemical Society.

Human skin cells have also been directly converted into neurons that can be used to study and find treatments for diseases in the brain, as well as liver cells and insulin - producing cells of the pancreas.

It is an autoimmune disease caused by cells of the immune system mistakenly attacking and destroying the insulin - producing cells of the pancreas.

In T1D, exposure to certain microbial species found in the gut may trigger an autoimmune response to the insulin - producing cells of the pancreas in susceptible individuals.

Type 1 diabetes is an autoimmune disease that occurs when the body attacks the insulin - producing cells of the pancreas, leaving people with no way to control their blood sugar, or blood glucose.

In type 1 diabetes, there is destruction of the insulin producing cells of the pancreas for reasons that are still largely unknown.

Unlike type 1 diabetes, type 2 is sometimes defined by the development of insulin resistance — a loss of sensitivity to the hormone — which causes the insulin - producing cells of the pancreas to work hard to overcome the resistance, and over time, stop functioning at all.

Dietary modification (if you can convince the cat to change) is useful even if the cat needs insulin, as the higher protein content of diabetic diets for cats means less work for the insulin - producing cells of the pancreas.

Not exact matches

This type of diabetes strikes in the early teenage years and begins with the immune system destroying the cells in the pancreas that produce insulin, according to Patrick Holford, founder of the Institute for Optimum Nutrition in London.

Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin - producing (islet, or islets of Langerhans) cells in the pancreas.

Over the past 15 years, the GFP gene has enabled scientists to watch a plethora of previously murky biological processes in action: how nerve cells develop in the brain, how insulin - producing beta cells form in the pancreas of an embryo, how proteins are transported within cells, and how cancer cells metastasize through the body.

By introducing caerulein to the pancreas we were able to generate new beta cells — the cells that produce insulin — potentially freeing patients from daily doses of insulin to manage their blood - sugar levels.»

This leads to high blood glucose values; the function of the insulin - producing cells in the pancreas is also negatively influenced.

In this type of diabetes, the body destroys insulin - producing cells in the pancreas, resulting in high blood glucose levels.

The four children also had more of the types of species that are known to trigger gut inflammation, a possible prelude to type - 1 diabetes, in which the body's immune system mistakenly produces antibodies that attack and destroy the beta cells of the pancreas that normally make insulin.

At the very least, Domínguez - Bendala hopes that they could use BMP - 7 to convert the other 98 per cent of donor pancreas cells into beta cells, which, he estimates, could potentially provide enough insulin - producing cells to transplant into seven people.

In type 1 diabetes, the immune system attacks and destroys insulin - producing cells in the islets of the pancreas.

In the case of type 1 diabetes, it destroys the insulin - producing cells in the pancreas, and in multiple sclerosis it strikes the central nervous system.

The mutant mice produced less insulin — the hormone made in the pancreas that helps cells burn sugar — and they were plump and diabetic, with high levels of glucose in their blood.

The most intriguing mutant type of mice were unusually thin; they generated more active osteocalcin, secreted more insulin, and produced many times more of the insulin - releasing cells in the pancreas.

Douglas Melton, codirector of the Harvard Stem Cell Institute in Cambridge, Massachusetts, and his colleagues study both the stem cells that develop into the pancreas and its insulin - producing cells and the genes that guide those cells» development.

He and his collaborators found that three transcription factors, when targeted to the pancreas of a living mouse, converted fully formed, non-insulin-producing pancreatic cells into cells that were functionally identical to insulin - producing cells — no stem cells required.

When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.

He had to have his pancreas removed, and instead of throwing his gland away, we took it back to the lab and got maybe 50,000 to 100,000 of these insulin - producing cells.

Like the childhood form, the insulin - producing beta cells of the pancreas are destroyed by the body's own immune system.

These are organized in germ layers and are thus the origin of different tissue types, including the pancreas and its insulin - producing beta cells.

Diabetes is characterized by a dysfunction of the insulin - producing beta cells of the pancreas.

A number of radiotherapies that marry a small but potent amount of radioactive material and a targeted molecular compound have been gaining traction as progressive treatments for malignant NETs, which can develop wherever nerve cells and hormone - producing endocrine cells are present (e.g., gastrointestinal tract, pancreas, lungs, thyroid).

A ONE - OFF treatment for diabetes is a step closer thanks to a better understanding of how human liver cells can be transformed into something like the beta cells that produce insulin in a healthy pancreas.

* In type 1 diabetes, the insulin - producing cells in the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cells).

The clusters» inner cells produced insulin, while outer cells produced glucagon and somatostatin, two proteins typical of pancreas cells, the team reports in a paper published online today by Science.

The deficit is most pronounced in type 1 diabetes, which develops when insulin - producing beta - cells of the pancreas are destroyed.

Type 1 diabetes is a disease caused by the destruction of the insulin - producing cells in the pancreas.

«In type 2 diabetes, glucose does not enter the cells and increased levels of insulin, resulting from an overburdened pancreas, do nothing to facilitate glucose entry into cells for producing energy,» Martins - Green said.

But before glucose can be tapped, it must be ushered into cells with the help of insulin, a hormone produced in the pancreas.

At the same time, 30 percent of those with type 2 diabetes had the same autoantibodies to their beta cells — the insulin - producing cells in the pancreas — associated with type 1.

For them, the loss of insulin - producing beta cells in their pancreas tends to be gradual, a result of overworking the cells.

Type 1 diabetes mellitus (T1D) begins with autoimmune destruction of insulin producing cells in the pancreas, usually in children.

Moreover, all of the donated pancreases displayed active insulin - producing beta cells, with some of the cells scattered individually and others clumped with different kinds of hormone - producing cells in the normal pancreatic structures called islets.

In pre-clinical experiments, hESC - derived cardiomyocytes engraft in damaged myocardium and appear to behave like native cells; hESC - derived islet cells engraft, produce the hormones of the endocrine pancreas, and appear to do so under homeostatic control; etc. \ n \ nThere is no evidence of teratomas from differentiated hESC - derived cells and minimal, if any, immune rejection.

In a study published in October 2008, Melton showed that it was possible to take an exocrine cell in the pancreas of a live mouse and turn it into an insulin - producing beta cell without first going back to an undifferentiated iPS state.

Gladstone scientist Dr. Sheng Ding has exposed more chameleon - like qualities of the human skin cell, using chemical cocktails to turn skin cells into fully functional brain, heart, liver, and insulin - producing pancreas cells.

β - cells are a type of cell that normally resides in the pancreas and produces a hormone called insulin.

Quiescent PSCs in a normal pancreas act as lipid - storing cells with a limited secretome, whereas activated PSCs in the tumor microenvironment produce a vast array of secreted proteins implicated in cancer progression.

We show here that human amylin is toxic to insulin - producing beta - cells of the adult pancreas of rats and humans.

ß - cells are a type of cell that normally resides in the pancreas and produces a hormone called insulin.

For patients with type 1 diabetes, and some cases of type 2 diabetes, the pancreas fails to produce effective beta cells, the cells that monitor blood sugar and release insulin to keep glucose levels normalized.

1) The discovery that pancreatic beta cells, which produce insulin, have the ability to be regenerated from stem cells or ductal cells in the pancreas, indicating that one potential treatment for type 1 diabetes is to stimulate beta cells to regrow even after many years of living with diabetes

The treatment could provide what the company calls a virtual cure for Type 1 diabetes, which is caused by a lack of insulin - producing «islet» cells in the pancreas.