The new procedure may lead to a cheap and easy way to create cow «drug factories» that reliably
produce human proteins — such as albumin, which restores osmotic pressure after major blood loss — in their milk.
The third patent was granted to scientists at Ohio University for a mouse that
produces human protein, beta interferon.
Erlacher and colleagues isolated HSCs from mice and infected them with a genetically engineered adenovirus that transiently
produces a human protein called BCL - XL that inhibits BIM and BMF.
For the animal experiments, Savio Woo of the Center for Gene Therapy at Baylor College of Medicine in Houston and his colleagues first isolated liver cells from transgenic mice that
produce the human protein a1 - antitrypsin in their livers, from where it is secreted into the blood.
Moderna is pioneering messenger RNA Therapeutics ™, an entirely new in vivo drug modality that
produces human proteins or antibodies inside patient cells, which are in turn active intracellularly or secreted.
Leveraging Moderna's messenger RNA Therapeutics ™ platform, an entirely new in vivo drug modality that
produces human proteins or antibodies inside patient cells, Onkaido plans to rapidly turn scientific innovation into cancer therapies that can make a real difference for patients.
Not exact matches
The gene
produces a
protein that is toxic to insects but harmless to
humans.
«We use non-GMO or organic soybeans, delivering
proteins for
human consumption that have been processed without any chemicals, with the bean
producing as much of the
protein as possible,» Nadler says.
In the same way that vegetables are loaded with unique phytochemicals — substances
produced by the plant that have benefits for
humans — these carry over into
protein powders made from those plants.
One of the main reasons for this is whey
protein's ability to help the
human body
produce glutathione.
2) Packed with
Protein: Organic barley grass powder contains 18 amino acids including a complete source of the essential amino acids the
human body needs but can not
produce by itself.
Your baby's brain
produces a
protein called
human growth hormone while he sleeps.
Human milk has a similar composition to that
produced by other precocial primates, relatively low in fat and
protein, but high in sugar (in the form of lactose)[4].
The study shows that a
protein produced by the Epstein - Barr virus, called EBNA2, binds to multiple locations along the
human genome that are associated with these seven diseases.
«Our work illustrates that this exquisite control mechanism — regulated by PUS7 and pseudouridine — is critical to adjusting the amount of
proteins needed for
human stem cells to grow and
produce blood,» says Cristian Bellodi.
Using
human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific
protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).
Scottish researchers took a similar approach to clone sheep that will
produce in their milk
human factor IX
protein, which is used to treat hemophilia.
In a first for any animal, including
humans, four cows injected with a type of HIV
protein rapidly
produced powerful antibodies against the virus, researchers report.
In tests in mice, a vaccine developed using
human malaria parasite
proteins — known as MSP -1-BBM — enabled the immune system to
produce antibodies in the bloodstream.
Using a genome - wide genetic screen, Dr. Gelman and colleagues identified a previously unknown metastasis suppressor — the FOXO4
protein, which belongs to a family of genes that are
produced by all
human cells.
Bacteria can be genetically modified to
produce various
proteins and other substances
humans need, so 3 - D printed bacterial materials may have many other medical uses, too.
Professor Ali Tavassoli, who led the study with colleague Dr. Ishna Mistry, explains: «In an effort to better understand the role of HIF - 1 in cancer, and to demonstrate the potential for inhibiting this
protein in cancer therapy, we engineered a
human cell line with an additional genetic circuit that
produces the HIF - 1 inhibiting molecule when placed in a hypoxic environment.
The strain
produces proteins that help it stick to food, and to the
human gut.
Since the February breakthrough, PPL Therapeutics of Edinburgh, which collaborates with the Roslin Institute, has
produced five lambs from fetal cells that were genetically modified to carry marker genes and genes for
human proteins.
The researchers observed the effect of the synthetically
produced molecule, JK - 31, on the growth and proliferation of a model
human breast cancer cell line and found that it effectively blocked the
protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.
Lambs
produced from the genetically manipulated cells
produce foreign
proteins; such animals may be able to manufacture large quantities of medically valuable
human proteins in their milk.
In the
human branch, however, two amino acids in the
protein produced by the FOXP2 gene changed notably over the course of just a few million years.
The ability to manufacture
proteins, which at present are very difficult or even impossible to
produce, in large quantities and in their native form, rapidly and inexpensively, will have an enormous impact in all sectors of biology (biotechnology, nutrition, pharmacy,
human and animal health care, and, in the near future, nanotechnology).
The glial cells
produced different versions of the
human APOE
protein, or had no APOE.
Therefore, the research shows that these mutations affecting the signalling route which depends on the ATM
protein, as well as the drugs inhibiting the function of this signalling route such as some anti-tumour drugs, could
produce infertility problems in
humans.
DNA that doesn't
produce proteins may be especially important for creating differences between
humans and other primates, biochemist Paulina Carmona - Mora reported October 18 at the annual meeting of the American Society of
Human Genetics.
In earlier studies involving animal models and
human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that
produces high levels of Mena, a
protein that enhances a cancer cell's ability to spread.
More studies are needed, but Krug believes new therapeutics could be designed to block the NS1
protein produced by the flu virus, hobbling its ability to evade the
human immune system.
Staining on these slides shows that engineered
human arteries
produce contractile
proteins (left) and calponin (right) just one week after being grown in culture.
It not only prevented the buildup of amyloid beta (Aß), a sticky
protein linked to Alzheimer's, but it also does not appear to
produce the dangerous side effects of earlier versions tested in
humans.
In both
humans and birds, cells process this gene in a way that
produces both a full - length
protein and a shorter version of the
protein.
The team led by Dr Rubén López — of the UAB's Department of Cell Biology, Physiology and Immunology and Institute of Neuroscience, and the Centre for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED)-- used a genetically modified mouse that
produces the
human form of IL - 37 to study the function of this
protein.
UBC Psychiatry Professor Dr. Weihong Song and Neurology Professor Yan - Jiang Wang at Third Military Medical University in Chongqing attached normal mice, which don't naturally develop Alzheimer's disease, to mice modified to carry a mutant
human gene that
produces high levels of a
protein called amyloid - beta.
One circuit senses levels of five different microRNAs, and if the levels match those typically found in
human cervical cancer cells, the circuit
produces a
protein that kills the cell.
Group A Streptococcus bacteria (red) coat their surfaces with M1
proteins (white), which «stiff - arm» natural antibiotics
produced by the
human body.
When transplanted into
human cells in the laboratory, the mammoth TRPV3 gene
produced a
protein that is less responsive to heat than an ancestral elephant version of the gene.
Even more encouraging, the engineered tissues still continued to
produce human neural, cartilage, and liver cell
proteins, the team reports online this week in the Proceedings of the National Academy of Sciences.
Now, Harry Moore and Bikem Soygur at the University of Sheffield, UK, have shown that a
protein called syncytin - 1,
produced by a gene that
humans gained from viruses 25 million years ago, probably plays a vital role in this process.
The neurodegeneration that the scientists observed was similar to what other researchers had found in flies
producing a
human Ataxin - 7
protein with the polyglutamine expansion.
Researchers have discovered that the toxic
protein responsible for progeria is actually
produced at low levels in all
humans, possibly accumulating as we age.
When they looked at their
human patients, they found that all had mutations in the SELENBP1 gene that
produces this
protein and they all had high levels of methanethiol and dimethyl sulfide in their blood.
This study, for the first time, proved that these cells continually
produce this
protein in
humans with asthma,» states O'Byrne.
To overcome this hurdle, researchers genetically engineered
human T cells to
produce a CAR
protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer.
While E. coli bacteria are part of the
human gut flora and usually not pathogenic, the strains classed together as EHEC
produce a dangerous Shiga toxin that enters the cells in the gut and inhibits
protein synthesis by cleaving ribosomal RNA.
Scientists have found a group of
human sequences — unrelated to those in mice — which are capable of
producing SINEUPs, which can pair with typical
protein - coding mRNAs and enhance their translation.