Sentences with phrase «producing huntingtin»
Yuan's team exposed human brain cells to Congo red between 6 and 48 hours after they began producing huntingtin.
http://www.sciencemag.org/ Not exact matches
In March Chris Ross and his colleagues reported that cells bearing mutant huntingtin could survive if they produced extra CBP.
The stutters produce long stretches of the amino acid glutamine in the huntingtin protein, and the resulting misshapen protein clumps up within neurons, destroying brain cells.
At the same point in the disease process, the scientists found no evidence of impairment in liver cells, which also produce the mutated huntingtin protein.
That means a healthy parent whose huntingtin gene encodes proteins with 35 repeats may produce a child with 36 repeats.
An approach to treating HD that uses targeted molecules to tell cells not to produce the harmful huntingtin protein
R6 / 2 mice have been genetically altered with an abnormal gene that makes them produce a harmful fragment of the mutant huntingtin protein
Note: these mice don't produce toxic mutant huntingtin protein.
More than 36 CAG repeats in the huntingtin gene will always lead to HD symptoms, if a person lives long enough, and longer CAG repeats tend to produce an earlier age of onset.
When a person has too many CAGs in a row near the start of the huntingtin gene, a harmful «mutant» form of the protein is produced based on the instructions in the gene.
It turns out that faulty processing of the huntingtin «recipe» produces a short, harmful fragment of the huntingtin protein.
It's the extra-long copy of the huntingtin gene that makes neurons sick, because it causes them to produce an extra-long, harmful version of the huntingtin protein.
That's not what we expect when patients are given huntingtin - lowering drugs, which might produce around 50 - 75 % reductions in the mutant and healthy protein.
It's the world's first trial in patients to slow, stop, prevent or reverse HD, using a method that targets the root cause of the disease, a gene producing a protein called huntingtin.