Sentences with phrase «producing islet cells»

ViaCyte is developing a drug delivery system that enables implanted pancreatic progenitor cells to survive and differentiate into functioning insulin - producing islet cells.

In addition, the molecular beacons technique http://www.lependart.com could have broad applications across regenerative medicine, because it could be used with other types of cells produced from stem cell cultures, such as brain cells or insulin - producing islet cells.

Combining a new hydrogel material with a protein that boosts blood vessel growth could improve the success rate for transplanting insulin - producing islet cells into persons with type 1 diabetes.

Mehlhaff CJ, Peterson ME, Patnaik AK, Carrillo JM: Insulin producing islet cell neoplasms: Surgical considerations and general management in 35 dogs.

Not exact matches

Usually, the body's own immune system — which normally fights harmful bacteria and viruses — mistakenly destroys the insulin - producing (islet, or islets of Langerhans) cells in the pancreas.

Once a significant number of islet cells are destroyed, you'll produce little or no insulin.

Islet autoimmunity, detected by antibodies that appear when the immune system attacks the islet cells in the pancreas that produce insulin, is a precursor to type 1 diabIslet autoimmunity, detected by antibodies that appear when the immune system attacks the islet cells in the pancreas that produce insulin, is a precursor to type 1 diabislet cells in the pancreas that produce insulin, is a precursor to type 1 diabetes.

Transplantation of pancreatic islets — cell clusters that contain insulin - producing cells — prevents severe, potentially life - threatening drops in blood sugar in people with type 1 diabetes, according to new research.

In type 1 diabetes, the immune system attacks and destroys insulin - producing cells in the islets of the pancreas.

New clinical trial results show that transplantation of pancreatic islets — cell clusters that contain insulin - producing cells — prevents severe, potentially life - threatening drops in blood sugar in people with type 1 diabetes.

People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.

Cannabinoids produced by the alpha cells may in fact activate cannabinoid CB1 receptors located in the pancreatic islets.

When the pancreatic islets, small masses of cells in the pancreas that produce insulin, are exposed to high levels of nutrients — as is the case among people who eat a lot — they become inflamed.

The pancreatic cells are supposed to mature into beta - islet cells, which produce the hormone insulin.

The cells also produce a hormone called islet amyloid polypeptide, or IAPP.

When they briefly exposed nestin - positive cells to a growth factor, the cells differentiated not only into neural cells but also into clusters that resemble the insulin - producing islets in the pancreas.

* In type 1 diabetes, the insulin - producing cells in the Langerhans islets of the pancreas are destroyed because they are attacked by the body's immune system (formation of islet autoantibodies against structures of the beta cells).

But the extracted tissue began producing insulin, glucagon and other hormones after the newly identified cells were added, indicating that they were indeed progenitors capable of differentiating into all the islet cell types, including beta cells.

More than half of islet cell tumors produce excessive gastrin, which stimulates the stomach to overproduce acid.

The remaining islet cell tumors may produce other hormones, such as vasoactive intestinal polypeptide, which can cause severe diarrhea and lead to dehydration.

«The loss of insulin - producing beta cells leads to type 1 diabetes, making it an ideal target for cell replacement therapy,» said James Shapiro, MD, PhD, FRCSC, Director of the Clinical Islet Transplant Program, University of Alberta.

After implantation, the cells are expected to mature into the full complement of islet cells, including insulin - producing beta cells, offering a potential functional cure for patients with high - risk type 1 diabetes.

Moreover, all of the donated pancreases displayed active insulin - producing beta cells, with some of the cells scattered individually and others clumped with different kinds of hormone - producing cells in the normal pancreatic structures called islets.

In pre-clinical experiments, hESC - derived cardiomyocytes engraft in damaged myocardium and appear to behave like native cells; hESC - derived islet cells engraft, produce the hormones of the endocrine pancreas, and appear to do so under homeostatic control; etc. \ n \ nThere is no evidence of teratomas from differentiated hESC - derived cells and minimal, if any, immune rejection.

«ViaCyte was the first to differentiate human stem cells into glucose - responsive, insulin - producing cells, and now we are running the first and only clinical trials of stem cell - derived islet replacement therapies for type 1 diabetes,» said Paul Laikind, PhD, President and CEO of ViaCyte.

The encapsulation of pancreatic islets within mainly alginate - based macro - or microcapsules with various physical configurations may allow protecting the islet graft without the need for immunosuppressive agents and moreover expanding the donor pool to animal tissue and novel insulin - producing cells.

The diabetic volunteer continued to produce insulin one year after she received a transplant of abdominal islet cells.

Novocell also demonstrated earlier this year, that hES - derived pancreatic progenitorsdevelop into human islet cells capable of producing insulin in response to glucose and ameliorating diabetes in animal models.

The piece mentioned that some of the funds would support ViaCyte and our efforts to develop and test the VC - 01 ™ product, comprised of an implantable device that holds precursor cells that upon implant in a patient are expected to differentiate to become pancreatic islet cells that produce insulin and other blood sugar - regulating hormones.

«These results suggest that, as a result of the FMD and re-feeding cycle, the pancreatic islets contain an elevated number of cells with features of progenitor cells, which may differentiate and generate insulin - producing cells,» noted the research.

Islet transplants Insulin is normally produced by islet or beta cells in the pancIslet transplants Insulin is normally produced by islet or beta cells in the pancislet or beta cells in the pancreas.

That's a reference to the multiple types of islet cells ViaCyte's technology produces.

These sentinel units will be removed at specific time points and examined histologically to provide early insight into the progression of engraftment and maturation into pancreatic islet cells including insulin - producing beta cells.

The treatment could provide what the company calls a virtual cure for Type 1 diabetes, which is caused by a lack of insulin - producing «islet» cells in the pancreas.

Chong Wee Liew, Ph.D., lead author and a postdoctoral researcher in the Kulkarni lab, first examined the expression of the tribbles protein in pancreatic islets (which house beta cells and other hormone - producing cells) in both humans and mice.

After implantation, these cells are expected to become mature human islet tissue including well - regulated beta cells producing insulin on demand.

The VC - 01 product candidate is the first embryonic stem cell - derived islet replacement therapy to reach clinical testing and is currently being evaluated in patients with T1D who have minimal to no insulin - producing beta cell function.

When implanted, PEC - 01 cells are expected to differentiate into pancreatic islet cells that produce insulin and other hormones that regulate blood sugar, while the Encaptra device is designed to protect the cells from immune destruction.

The far more nuanced and precise data produced by single cell analyses will allow for better understanding of pancreatic islet function and dysfunction at the cellular level.

To create a lasting source of insulin - producing beta cells for transplant, we are developing new methods to promote differentiation from pancreatic stem cells into healthy islets.

Type 1 Diabetes mellitus (T1D) is an autoimmune disorder characterized by a loss of function of insulin producing beta cells in pancreatic islets of langerhans leading to insulin insufficiency.

Poster: In vitro generation of insulin producing cells with insulin secretion kinetics and mitochondrial respiration similar to adult human islets [Poster T2190] Speaker: Dr. Alireza Rezania, Senior Director, Discovery Date / Time: June 23, 7:00 p.m. to 8:00 p.m., PDT

So too do the islet cells that manufacture insulin in the pancreas die when drugs, nay doctors, whip them to keep producing more insulin when they are tired and sick.

A novel investigative study published in the Nov 2014 issue of the Journal of Endocrinology looked at the effects of curcumin on insulin - producing cells within the pancreas called Beta cells (or B - cells) and Islet cells, in relation to imbalanced blood sugar.

Antibodies against the inflamed pancreatic cells are created and this process leads to dysfunction and destruction β - cells of the islets of Langerhans where insulin is produced.

The islet cells in these animals are destroyed and can not produce insulin.

The distinct endocrine glands are the adrenals, thyroid, parathyroids, pituitary gland and islets in the pancreas, although hormones are produced by many cells in other tissues.

The groups of cells in the islets that produce insulin are called beta cells.

A number of mechanisms are responsible for decreased insulin secretion or resistance, but most involve destroying islet cells, the cells of the pancreas that produce insulin.

Diabetes is caused by degeneration of insulin - producing cells in the pancreas (in the Islets of Langerhaans to be precise).