Sentences with phrase «production of amyloid plaques»
«We think about the slow production of amyloid plaques over decades and in this mouse model, a bacterial infection could cause full - blown plaques overnight.»
https://www.the-scientist.com/ Not exact matches
Disease - linked mutations in these genes result in increased production of the 42 - amino - acid form of the peptide (Abeta42), which is the predominant form found in the amyloid plaques of Alzheimer's disease.
Testosterone lowers the production of beta amyloid, a plaque associated with Alzheimer's disease.
These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal neurons; a decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.