Not exact matches
In these non-kidney sites,
calcitriol seems to serve an altogether different purpose: it appears to play no role in regulation
of minerals, and its
production is induced by inflammation rather than by the hormones that control
calcitriol synthesis in the kidneys.
Importantly, deleting these regions affected the response
of vitamin D activation to hormones, but not to inflammation - related molecules, indicating that these regions were key to allowing researchers to separately study the two types
of calcitriol production.
Understanding the function
of non-kidney
calcitriol production and its connection to inflammatory diseases, ranging from multiple sclerosis to arthritis, is
of great interest to a number
of biomedical researchers, who would like to know whether and how vitamin D could potentially be used to treat these diseases.
Calcitriol, the hormonally active form
of vitamin D, accumulates in the adrenals, and this stimulates the
production of the gene for tyrosine hydroxylase, which is involved in serotonin
production.