Sentences with phrase «progenitor cell development»
In collaboration with colleague Aaron Dinner, the research team also formulated a mathematical model that depicts the regulatory network governing progenitor cell development.
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«What's really exciting about this was that the activity differences were detected at a critical time in brain development: when neural progenitor cells are proliferating and expanding in number, just prior to producing neurons,» Silver said.
This is because larger brain parts are thought to have a later and longer process of neurogenesis — the development of neurons or nerve cells from neural stem cells and progenitor cells.
An example of epigenetic modifications leading to cancer progenitor cell formation possibly occurs in leukemia development.
«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.
These progenitor cells are often drug resistant and can initiate cancer development and are possibly involved in cancer relapse.
All stem cells are immature cells known for their ability to multiply indefinitely and give rise to progenitor cells that mature into specific cell types that populate the body's tissues during embryonic development.
This discovery lays the groundwork for a better understanding of the role progenitor cells can play in immune system response and could lead to the development of more effective therapies for a wide range of diseases.
Somehow, this lengthening of metaphase early in development appears to cause more progenitor cells to be made later, Huttner says.
«Early in development, all the cells are immature progenitors that are rapidly growing and dividing.
Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.
PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.
But the identity of the progenitor, or stem cells, that give rise to Merkel cells during embryonic development and adulthood is unclear.
The success of this research in determining a culture method that artificially increases both the amount of kidney progenitor cells and their viability time is a major development for the field.
Nephron progenitor cells (NPCs), at least in humans, normally only exist during a brief stage of embryonic development.
Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.
Wang and other colleagues previously discovered a molecule (called compound C) that converts stem cells into «neural progenitor cells,» an early stage in the cells» development into neurons.
They are produced during development from stem cells called glial progenitors.
«If infection occurred very early in development, the virus mostly infected the mini-brains» neural progenitor cells, and the effects were very severe.
A few years ago, Singh and colleagues identified a transcription factor called PU.1 that acts as the primary signal, a central genetic switch to initiate development of myeloid progenitor cells.
A normally functioning adult human brain has the ability to partially replenish or repair itself through neurogenesis, the proliferation and development of adult neural progenitor / stem cells (aNPCs) into new nerve cells.
Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.
The PEC - Encap ™ (also known as VC - 01) product candidate is designed to deliver the same pancreatic progenitor cells in an immunoprotective device and is currently in active development as a therapy for all patients with type 1 diabetes as well as insulin requiring patients with type 2 disease.
Telomerase is believed to play a role in the normal development of progenitor cells.
To develop protocols for production of transplantable mesDA and striatal GABAergic progenitors from human ES and NS cell lines, building on recent developments in stem cell biology;
Silent development of memory progenitor B cells.
5/15/2008 New Role Found for a Cardiac Progenitor Population In a discovery that could one day lead to an understanding of how to regenerate damaged heart tissue, researchers at the University of California, San Diego have found that parent cells involved in embryonic development of the epicardium — the cell l...
The Zika virus also replicated the genetic defect in another way, depleting the progenitor cells and causing similar development problems to the ones that Lancaster had observed in Vienna.
This visualization shows tightly - packed DNA in a mouse cell's nucleus at different stages of development, seen here in a semi-triangular form as a mature nerve cell; in a roundish shape as a multipotent stem cell; in a more oval form as a neuronal progenitor; and as a more fragmented structure that shows how removing a specialized binding protein (HP1β knockout) affects the structure of the DNA - packing material, called heterochromatin, in a mature neuron.
These renderings show a tightly packed form of DNA called heterochromatin as it exists in a mouse cell's nucleus at different stages of cell development: a multipotent stem cell (left), a neuronal progenitor (middle), and a mature nerve cell (right).
In the lab for Human Brain and Neural Stem Cell Studies we aim at developing experimental paradigms to systematically identify novel types of neural stem and progenitor cells that serve as building blocks for brain development.
Stem cells and progenitors in liver development.
Their system was based on earlier studies in which Singh and his colleagues identified a transcription factor called PU.1 as a central genetic switch that triggers development of myeloid progenitor cells.
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.
This confirms the vital role of «developmental engineering,» in which natural processes are mimicked to control the development and specification of adult stem and progenitor cells.
Most of these CSCs have been identified using surface markers that identify their corresponding normal tissue stem and progenitor cells, thus reinforcing the resemblance of tumor development to normal organogenesis.
By examining fetal mouse livers, which are rich sources of red blood cells and their progenitors, Wenqian Hu screened the various stages of red blood cell development for the presence of lncRNAs.
We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.
We have previously reported that our 26 - d protocol closely recapitulates key stages of biliary development, starting with the differentiation of hPSCs into endoderm and subsequently into foregut progenitor (FP) cells, followed by the generation of hepatoblasts (HBs), cholangiocyte progenitors (CPs) expressing early biliary markers and mature CLCs displaying cholangiocyte functionality.
BETHESDA, MD — Infection with Zika virus disrupts fetal brain development by interfering with the proliferation of human neural progenitor cells (hNPCs), a type of cell that drives neurodevelopment and proliferates into brain and nervous system cells, according to research presented at the American Society of Human Genetics (ASHG) 2016 Annual Meeting in Vancouver, B.C.
«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM and the article's corresponding author.