Mutations may bias
progenitor cell fate towards proliferation.
He is interested in the molecular control of stem and
progenitor cell fate decisions.
Title: Distinct regulatory cascades govern extraocular and pharyngeal arch muscle
progenitor cell fates Authors: Sambasivan R, Gayraud - Morel B, Dumas G, Cimper C, Paisant S, Kelly RG and Tajbakhsh S Date: June 2009 Publication Details: Developmental Cell 2009 June 16 (6): 810 - 821
Not exact matches
This pattern arises when uniform fields of
progenitor cells diversify their molecular
fate while adopting higher - order structure.
«This study can further our shared understanding of how the microenvironment can regulate the differentiation and
fate of a
progenitor or stem
cell.»
These results suggest the
fate of pluripotent
cells may be purposely altered to generate multipotent retinal
progenitor cells, which differentiate into functional retinal
cell classes and form a neural circuitry sufficient for vision.
HTT modulates mitotic spindle orientation and
cell fate in mouse cortical
progenitors from the ventricular zone.
Several
progenitor cells,
cells that appear to be committed to their
fate but not yet fully differentiated, have been shown to be capable of dedifferentiating into a different
cell type; this process is called transdetermination.
(
Progenitor cells are like stem
cells in that they can differentiate into different
cell types, but
progenitors»
fates are more limited and they can replicate only a restricted number of times.)
Specifically, we investigate the molecular events regulating developmental decisions that instruct cardiac
progenitor cells to adopt a cardiac
cell fate and subsequently fashion a functioning heart.
Specifically, we study the molecular events regulating early and late developmental decisions that instruct
progenitor cells to adopt a cardiac
cell fate and subsequently fashion a functioning heart.
Title: Pax3: Foxc2 Reciprocal Repression in the Somite Modulates Muscular versus Vascular
Cell Fate Choice in Multipotent
Progenitors Authors: Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME Date: 2009 Publication Details: Developmental
Cell.
May 25, 2000 Different levels of transcription factor coax immune
cell progenitors down different developmental pathways Researchers from the University of Chicago provide evidence that varying levels of a single transcription factor can determine the
fates of developing
cells.
Differentiation into extraembryonic endoderm [21] or neural
progenitors [33] are frequent early outcomes of spontaneous differentiation when human ES
cells are cultured in the presence of a feeder
cell layer, and it is interesting to speculate that the
cells are being primed for these
fates.