Immunocytochemical staining for Ki67 (cell proliferation marker), Sox2 (neural stem cell marker), Olig2 (
progenitor cell marker), and GFAP (glial fibrillary acidic protein, a marker for differentiated astrocytes) captured by confocal microscopy imaging.
(C) Confocal image of P150 dystrophic inner retina transplanted with hNPCctx — GDNF and double stained with antibodies against nestin, a neural stem and
progenitor cell marker (green) and human nuclear antigen (red).
Holoclones express high levels of stem and
progenitor cell markers CD44, α2β1 integrin, and β - catenin.
In support, PC3 cell holoclones, but not meroclones and paraclones, express three well - established stem and
progenitor cell markers.
Not exact matches
When Busch turned on the
marker in adult animals, it became visible that at least one third (approximately 5000
cells) of a mouse's hematopoietic stem
cells produce differentiated
progenitor cells.
At one end of the neuroepithelium, a region developed that was positive for
markers of
progenitors of granule and deep cerebellar nuclei projection neurons and negative for Purkinje -
cell markers, and whose origins could be traced to the rhombic lip zone of the cerebellar plate.
Some patients who received GM - CSF experienced above - average increases in the levels of
progenitor cells, defined as carrying the
marker CD34.
Using transgenic
markers and live imaging we are starting to describe the
cell behaviours and
progenitors that underpin limb regeneration.
Stage - specific embryonic antigen - 4 is not a
marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal
progenitor cells.
The authors used the
cell surface
marker podoplanin as a handle for isolating the
progenitor cells from bone marrow.
Lineage - restricted
progenitors are identifiable by expression of distinct combinations of
cell surface
markers.
Most of these CSCs have been identified using surface
markers that identify their corresponding normal tissue stem and
progenitor cells, thus reinforcing the resemblance of tumor development to normal organogenesis.
We have previously reported that our 26 - d protocol closely recapitulates key stages of biliary development, starting with the differentiation of hPSCs into endoderm and subsequently into foregut
progenitor (FP)
cells, followed by the generation of hepatoblasts (HBs), cholangiocyte
progenitors (CPs) expressing early biliary
markers and mature CLCs displaying cholangiocyte functionality.
The success of
marker - based approaches for dissecting haematopoiesis in mouse and human is reliant on the presence of well - defined
cell surface
markers specific for diverse
progenitor populations.
The fact that all three
markers are expressed in essentially all
cells in the holoclones suggests that these three molecules are probably expressed in both cancer stem and
progenitor cells.