Sentences with phrase «progenitor cells in»

We also analyzed the hematopoietic stem cells and various progenitor cells in the bone marrow.

The PEC - EnCap (formerly VC - 01 ™) product candidate delivers pancreatic progenitor cells in an immunoprotective device and is currently being evaluated in a Phase 1/2 trial in patients with type 1 diabetes who have minimal to no insulin - producing beta cell function.

These cells return to a precursor stage following their spontaneous fusion with transplanted haematopoietic stem and progenitor cells in damaged retinas.

Therefore, progenitor cells in wild - type dauer larvae maintain their ability to give rise to all proper cell types.

Besides having less angiogenesis, the older brains also had a smaller pool of progenitor cells in one area of the hippocampus.

PEC - Direct product candidate delivers the pancreatic progenitor cells in a non-immunoprotective device and is being developed for type 1 diabetes patients that have severe hypoglycemic episodes, extreme glycemic lability, and / or impaired awareness of hypoglycemia.

The PEC - EnCap (formerly VC - 01 ™) product candidate delivers pancreatic progenitor cells in the Encaptra ® immunoprotective device, and is currently being evaluated in a Phase 1/2 trial in patients with type 1 diabetes who have minimal to no insulin - producing beta cell function.

Social isolation prevents exercise - induced proliferation of hippocampal progenitor cells in female rats.

The PEC - Direct product candidate delivers stem cell - derived PEC - 01 pancreatic progenitor cells in a device designed to allow direct vascularization of the cells, and is being developed for type 1 diabetes patients that have severe hypoglycemic episodes, extreme glycemic lability, and / or impaired awareness of hypoglycemia.

, van Boxtel, R., Wongvipat, J., Dowling, C.M., Gao, D., Begthel, H., Sachs, N., Vries, R.G., Cuppen, E., Chen, Y., Sawyers, C.L., Clevers, H.C. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

A recent study shows that male - pattern baldness may be caused by a lack of progenitor cells in hair follicles.

Hutter G and Thiel E Allogeneic transplantation of CCR5 - deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2.

Is there a role for chromaffin progenitor cells in neurodegenerative diseases?

Title: Numb Promotes an Increase in Skeletal Muscle Progenitor Cells in the Embryonic Somite Authors: Jory A, Le Roux I, Gayraud - Morel B, Rocheteau P, Cohen - Tannoudji M, Cumano A, Tajbakhsh S Date: 2009 Publication Details: Stem Cells; Volume 27, Issue 11.

This VCAM - 1 - VLA - 4 interaction between bone marrow stromal cells and bone marrow progenitor cells helps to retain the progenitor cells in the bone niche.

Discovered a series of signaling events beginning with the morphogen Sonic hedgehog (Shh) that are essential for guiding a population of late cardiac progenitor cells in the outflow tract of the heart.

Osteogenic induction of human bone marrow - derived mesenchymal progenitor cells in novel synthetic polymer - hydrogel matrices.

Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat.

Bone marrow CD169 + macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.

Cytokine expression by human marrow - derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL - 1 alpha.

Recent evidence suggests the existence of progenitor cells in adult tissues that are capable of differentiating into vascular structures as well as into all hematopoietic cell lineages.

For the other adult patients that might still benefit from a cord blood donor, either two cord blood units are combined for a single transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or progenitor cells in the laboratory before infusion or modify the cells in some way to make them more potent at the time of transplant.

Osteogenic differentiation of mesenchymal progenitor cells in computer designed fibrin - polymer - ceramic scaffolds manufactured by fused deposition modeling.

The PEC - Direct ™ product candidate delivers the pancreatic progenitor cells in a non-immunoprotective device and is being developed for type 1 diabetes patients who have severe hypoglycemic episodes, extreme glycemic lability, and / or impaired awareness of hypoglycemia.

Extra note: see this recent ECCRI paper on circulating progenitor cells in people who have inherited very high cholesterol.

The PEC - Encap ™ (also known as VC - 01) product candidate is designed to deliver the same pancreatic progenitor cells in an immunoprotective device and is currently in active development as a therapy for all patients with type 1 diabetes as well as insulin requiring patients with type 2 disease.

Patients with ExMI tended to have a decrease (18 percent) in the levels of progenitor cells in their blood, while the rest of the group saw an increase (14 percent).

Cortical neural progenitor cells in turn give rise to immature neurons.

Individual neural progenitor cells in culture produce different neuron types as time goes by, starting with the innermost cells (green) and followed by more superficial neurons (red).

Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

When they deleted the SCF gene in the hair progenitor cells in mouse models, the animal's hair turned white.

Different sets of progenitor cells in the heart give rise to two different types of heart cells — muscle and nonmuscle.

They grew human hippocampal progenitor cells in a dish and added sertraline.

By using genetic «signatures», we were able to compare the blood progenitor cells responsible for overproducing megakaryocytes in our model, to progenitor cells in people with essential thrombocythemia.

We were able to show that progenitor cells in our model and in patients with essential thrombocythemia, had a signature of excessive thrombopoietin stimulation.

By the 1970s researchers had recognized another type of progenitor cell in the adult bone marrow, which they named the mesenchymal stem cell.

Darbepoietin - Alfa after High - Dose Melphalan and Autologous Hemopoietic Progenitor Cell in Multiple Myeloma Patients: A Pilot Study

Not exact matches

It's blood in a newborn baby's umbilical cord that's rich in a type of stem cell called hematopoietic progenitor cells (HPCs).

Transient Silencing of 14 -3-3sigma promotes proliferation of p63 - positive progenitor cells isolated from human breastmilk in mammary epithelial cell culture.

«We've shown that SIF - seq can be used to identify enhancers active in cardiomyocytes, neural progenitor cells, and embryonic stem cells, and we think that it has the potential to be expanded for use in a much wider variety of cell types,» Dickel says.

«What's really exciting about this was that the activity differences were detected at a critical time in brain development: when neural progenitor cells are proliferating and expanding in number, just prior to producing neurons,» Silver said.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

The findings, from the Emory / Johns Hopkins / Florida State team that showed this spring that neural progenitor cells are particularly vulnerable to Zika infection, were published in Nucleic Acid Research.

The neural progenitor cells used were derived from iPSCs (induced pluripotent stem cells), which were in turn derived from donor skin cells.

This study, «Engineered epidermal progenitor cells can correct diet - induced obesity and diabetes,» is the first to show that an engineered skin graft can survive long term in wild - type mice with intact immune systems.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

Both Zika strains were able to infect and cause cell death in neural progenitor cells.

This type of stem cell, called an oligodendrocyte progenitor cell, is found in the brain and spinal cord.

But it was another three decades before Klassen — who has used retinal progenitor cells to restore vision in mice, cats, dogs and pigs — could conduct human trials involving retinitis pigmentosa.