For the other adult patients that might still benefit from a cord blood donor, either two cord blood units are combined for a single transplant, or more recently, there are some exciting new graft engineering technologies that are emerging to expand stem or
progenitor cells in the laboratory before infusion or modify the cells in some way to make them more potent at the time of transplant.
Not exact matches
In conjunction with the
laboratory of Matthew J. Evans, PhD, from the Department of Microbiology at Icahn School of Medicine at Mount Sinai, investigators demonstrated the functionality of the liver
cells generated from the
progenitors, as the liver
cells can be infected by the hepatitis C virus, a property restricted to liver
cells exclusively.
A team from Cold Spring Harbor
Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis
in mice by preventing mini-tumors
in the lungs from recruiting stem
cells called endothelial
progenitors, which assemble into blood vessels to nourish the malignancy.
These
cells were then grown
in the
laboratory under special conditions to select for stem - like
cells called endothelial
progenitor cells.
Researchers from the
laboratories of Hiroshi Y. Yoshikawa and Hideki Taniguchi had previously demonstrated the
in vitro formation of a 3D transplantable liver «organ bud» from human induced pluripotent stem
cells (iPSCs) co-cultured with mesenchymal and endothelial
progenitors, and allows for the growth of a small vascularized and functional organ [1 - 3].
Supported by a CIRM translational grant, scientists
in Huang's
laboratory are using human stem
cells to create inhibitory neuron
progenitors — early - stage brain
cells that can develop into mature inhibitory neurons.
In the November 6 Nature Methods, the team led by Bing Lim and Massimo Nichane of the Genome Institute of Singapore and Kyle M. Loh of Stanford University School of Medicine, and including Siva V, Ph.D., of The Jackson Laboratory's Single Cell Biology Lab, showed that mouse Sox9 + multipotent embryonic lung progenitors can be isolated and expanded long - term in 3D cultur
In the November 6 Nature Methods, the team led by Bing Lim and Massimo Nichane of the Genome Institute of Singapore and Kyle M. Loh of Stanford University School of Medicine, and including Siva V, Ph.D., of The Jackson
Laboratory's Single
Cell Biology Lab, showed that mouse Sox9 + multipotent embryonic lung
progenitors can be isolated and expanded long - term
in 3D cultur
in 3D culture.