Sentences with phrase «progenitor cells into»

The researchers then transplant these progenitor cells into the hippocampi of mice that carry the apoE4 gene and model aspects of Alzheimer's disease.

The study supports the idea that patients with coronary artery disease may benefit from cardiac rehab programs, which drive the progenitor cells into the ischemic tissue, so they can contribute into vascular repair and regeneration.

In this work, we transplanted hematopoietic stem and progenitor cells into the substantia nigra of brains of two different mouse models of Parkinson's disease.

In the new study, Makarenkova and her colleagues looked at whether they could kick start regeneration by injecting progenitor cells into the lobes that make up the lacrimal gland.

Next, the researchers differentiated the progenitor cells into networks of cortical neurons, the primary functional cell type of the brain's cortex (gray matter).

Not exact matches

After 20 years developing their method, they say they can turn the progenitor cells that are inside seminiferous tubules, called spermatogonia, into mature sperm.

To create an egg, a progenitor cell called an oocyte divides into two daughter cells: a hulking egg cell and a wimpy polar body.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

Progenitor cells are early descendants of stem cells that can differentiate into one or more specific cell types.

The researchers then used a 3 - D cell culture system to coax their mutant and healthy hPSCs down the differentiation pathway into becoming kidney progenitor cells and finally the proximal tubule cells found in kidney nephrons.

The researchers also employed a cutting - edge technology developed by their collaborators at Columbia University to reprogram the child's skin cells into early progenitor cells, then differentiate those into lung cells, the front lines of influenza infections.

All stem cells are immature cells known for their ability to multiply indefinitely and give rise to progenitor cells that mature into specific cell types that populate the body's tissues during embryonic development.

Now, scientists at Boston University's Center for Regenerative Medicine (CReM) have announced two major findings that further our understanding of this process: the ability to grow and purify the earliest lung progenitors that emerge from human stem cells, and the ability to differentiate these cells into tiny «bronchospheres» that model cystic fibrosis.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

It is a really amazing and simple mechanism, and by affecting the progenitor cells» so - called polarity we can control their conversion into beta cells», says Pia Nyeng.

The Duke team had previously established that Type 2 cells produce surfactant and function as progenitors in adult mice, demonstrating differentiation into gas - exchanging Type 1 cells.

Understanding stem / progenitor cells — which can develop into various types of tissue — are key to developing novel approaches for regenerative medicine.

All formed the same types of stem cells, which give rise to «progenitor» cells that, in turn, divide into neurons and eventually organize themselves in six layers of brain tissue.

Dr. Gabriel Ferguson, a postdoctoral fellow in the lab of Dr. Martinez - Agosto and first author of the study, built upon the lab's previous research that utilized the blood system of the fruit fly species Drosophila, showing that a specific set of signals must be received by progenitor cells to activate their differentiation into cells that can work to fight infection after injury.

Scientists in Germany last year reported that they could transform adult mouse spermatogonial progenitors into cells genetically resembling ESCs by using a different growth medium for just a few weeks.

In addition, we were able to differentiate these cells into neurons — and that's a characteristic of all neural crest - derived tissue and its progenitors»

Most of these trials involve stem cell - derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

On a molecular level this process is controlled by a wide range of factors, ensuring that the right number of undifferentiated progenitor cells differentiate into skin cells and make their way to replace the old damaged ones.

Each progenitor cell adapts to the needs of its environment and integrates itself into the body where new cells are needed.

In donors, blocking the interaction between Del - 1 and hematopoetic stem cells could enhance the mobilization of those progenitors into the bloodstream.

Hwang and his team harvested stem cells — the self - renewing progenitors of all cells in the body — from cloned early - stage embryos made by slipping the nucleus of a skin cell into a nucleus - free egg.

One promising way to treat diseased or damaged kidneys is cell therapies that include the transplantation of renal progenitor cells, which can then develop into the cells needed for full recovery.

In order to learn more about this process, Alexander Skupin and his team treated blood stem cells from mice with growth hormones and then watched closely how these progenitor cells behaved during their differentiation into white or red blood cells.

Acquiring a sufficient number of progenitor cells has been difficult, however, which is why scientists have considered induced pluripotent stem cells (iPSCs), since they can be expanded at significantly high levels and then differentiated into the progenitors.

In those cases, the NPCs often matured into adult kidney cells in a manner of days, leaving no steady population of progenitor cells to study.

In samples from the same individuals, stem cells that had matured into so - called «progenitor cells» were 10 to 100 times as abundant on hairy patches as on bald ones, suggesting they are the key to hair growth.

One possibility would be to take stem cells from balding men, multiply these into progenitor cells, and then return them to the scalp.

They then transplanted progenitors of the inner ear cells into the inner ear of embryonic normal and Connexin 30 knockout mice using glass tubes with optimized tip sizes.

Progenitor cells grown from the skin of ALS (Lou Gehrig's disease) or spinal muscular atrophy patients can be transformed into various neural cells to model each disease and allow rapid drug screening, Zhang adds.

To make the cells, Sundberg first created induced pluripotent stem cells from patients» blood cells or skin cells, then differentiated these into neural progenitor cells and finally Purkinje cells.

But he adds that the study does not show that human astrocytes are genetically normal when engrafted into the mouse brain, and it does not rule out the idea that the improved learning and memory «could be due to the persisting progenitor cells.»

Wang and other colleagues previously discovered a molecule (called compound C) that converts stem cells into «neural progenitor cells,» an early stage in the cells» development into neurons.

In the new study, Qu discovered that adding the signaling molecules at Day 3 worked much better: The neural progenitor cells quickly and efficiently differentiated into motor neurons.

But the extracted tissue began producing insulin, glucagon and other hormones after the newly identified cells were added, indicating that they were indeed progenitors capable of differentiating into all the islet cell types, including beta cells.

This requires the activation of progenitor keratinocyte (PK) cells that turn into new follicles.

Ten people will receive injections into the injury site of hESC - derived oligodendrocyte progenitor cells, which stimulate the growth of new and severed nerves and recoat damaged nerves with myelin.

With PAR3 out of the picture, neural stem cells and progenitors are free to differentiate into new neurons and glia.

The current study did something similar in the spine, turning scar - forming astrocytes into progenitor cells called neuroblasts that regenerated into neurons,» said Dr. Chun - Li Zhang, assistant professor of molecular biology at UT Southwestern and senior author of both studies.

Most of these trials involve stem cell — derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

Their studies have shown that, while progenitor cells can give rise to benign lesions, only stem cells have the capacity to develop into deadly invasive tumours.

Progenitor cells grown from the skin of ALS or spinal muscular atrophy patients can be transformed into various neural cells to model each disease and allow rapid drug screening.

The researchers donned their thinking caps to explain how neural stem and progenitor cells differentiate into neurons and related cells called glia.

The overall aim of this study was to determine if pluripotent cells overexpressing these transcription factors could be intentionally driven toward retinal progenitors that differentiate into multiple retinal cell classes and form a functional retina.

A normally functioning adult human brain has the ability to partially replenish or repair itself through neurogenesis, the proliferation and development of adult neural progenitor / stem cells (aNPCs) into new nerve cells.