Sentences with phrase «prognostic marker in»

We can envision that DAXX can serve as a precise prognostic marker in PCa and that tissue - specific shRNA delivery targeted against DAXX can be employed in the treatment of metastatic prostate cancer in patients, in particular if we discover, through additional studies, that DAXX is a marker for lethal PCa in humans.

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after multivariable adjustment.

The primary tumor location was an independent prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results of an analysis (abstract 3503) of data from CALGB / SWOG 80405 presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting.

It could be suggested that Cyclin D1 protein may be a valuable prognostic marker in IDC and can be targeted in the future therapeutic approaches.

Plasma levels of sNKG2D - L, and verexpression of ADAM10, correlate with disease progression and are prognostic marker in some hematologic malignancies, including Hodgkin lymphomas (HL).

Not exact matches

A research group headed by Gustavo Turecki, professor of psychiatry at McGill University in Montreal, Canada, recently used the platform to show that miRNAs can be used as prognostic markers for therapeutic responses to an antidepressant medication in patients with major depressive disorder (3).

Their presentation is entitled «High expression of AF1q is an adverse prognostic factor and a prediction marker of extramedullary disease in multiple myeloma.»

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

Angiotropism is a marker of extravascular migration of melanoma cells along vascular and other structures and a prognostic factor in cutaneous melanoma.

In harmony to the present suggestion, the scoring and image cytometry evaluation using immunohistochemistry of Cyclin D1 protein marker stated that the variations of protein expression in tissue sections could yield prognostic information or could be useful in determining subtle effects of curative or prevention therapies [31In harmony to the present suggestion, the scoring and image cytometry evaluation using immunohistochemistry of Cyclin D1 protein marker stated that the variations of protein expression in tissue sections could yield prognostic information or could be useful in determining subtle effects of curative or prevention therapies [31in tissue sections could yield prognostic information or could be useful in determining subtle effects of curative or prevention therapies [31in determining subtle effects of curative or prevention therapies [31].

«In the preplanned biomarker analysis, the expression of pSTAT3 detected by immunohistochemistry was both a prognostic marker and a predictive biomarker of benefit from napabucasin,» the researchers wrote.

SO, they had suggested the inhibition of cyclin Dl / CDK4 activity might be important in considering drugs of future therapies [25], also, they reported that Cyclin D1 was considered as a significant prognostic marker.

Also the prognostic marker of HER2 \ neu positive expression resulted in 77.8 % of GII and 75 % of GIII cases.

In patients with metastatic breast cancer, our large multicenter study confirmed that CTC can be used as a prognostic marker and that dynamic early changes during chemotherapy are associated with the treatment outcome (Pierga, Ann Oncol 2012).

We demonstrated that the other MAP3K, MAP3K8, accumulates in high - grade ovarian carcinomas and is a new prognostic marker for these tumours.

We conducted a meta - analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity of circulating tumor cell (CTC) detection as a prognostic marker.

Known and novel independent prognostic markers were identified in our cohort of proteasome inhibitor and IMiD - treated patients with long follow - up, including events with context - specific prognostic value, such as deletions of the PRDM1 gene.

The cytotoxicities of IMGN632 and X-ADC were first assessed in a panel of AML cell lines, which expressed CD123 at levels similar to AML blast cells (ABC values, 1100 - 13000) and encompassed a variety of poor prognostic markers (Table 1).

A randomized pilot trial of oral branched - chain amino acids in early cirrhosis: validation using prognostic markers for pre-liver transplant status.