Finally, we ask whether the mechanical differences between normal and cancer cells can be used as diagnostic or
prognostic markers of cancer progression.
Also
the prognostic marker of HER2 \ neu positive expression resulted in 77.8 % of GII and 75 % of GIII cases.
Not exact matches
A research group headed by Gustavo Turecki, professor
of psychiatry at McGill University in Montreal, Canada, recently used the platform to show that miRNAs can be used as
prognostic markers for therapeutic responses to an antidepressant medication in patients with major depressive disorder (3).
Their presentation is entitled «High expression
of AF1q is an adverse
prognostic factor and a prediction
marker of extramedullary disease in multiple myeloma.»
«Cadherin - 22 could be a powerful
prognostic marker for advanced cancer stages and patient outcomes,» said lead author Prof. Jim Uniacke, Department
of Molecular and Cellular Biology.
Detection
of miR - 34a inactivation may therefore represent a useful
prognostic marker,» says Hermeking.
The researchers believe that they have identified a group
of RNA molecules — known as long noncoding RNAs (lncRNAs)-- that hold the potential for serving as better
prognostic markers for prostate cancer.
The key experiments included for replication were selected because they examine the induction
of POSTN expression in the pulmonary stromal fibroblasts and test the role
of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role
of POSTN as a possible
prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).
Angiotropism is a
marker of extravascular migration
of melanoma cells along vascular and other structures and a
prognostic factor in cutaneous melanoma.
Plasma levels
of sNKG2D - L, and verexpression
of ADAM10, correlate with disease progression and are
prognostic marker in some hematologic malignancies, including Hodgkin lymphomas (HL).
Are these
markers prognostic and do they tell clinicians about potential eligibility
of other types
of therapies, including those under development?
The primary tumor location was an independent
prognostic marker in patients with RAS wild - type metastatic colorectal cancer after adjusting for age, gender, synchronous / metachronous disease, consensus molecular subtype, and microsatellite instability and molecular status, according to the results
of an analysis (abstract 3503)
of data from CALGB / SWOG 80405 presented at the 2017 American Society
of Clinical Oncology (ASCO) Annual Meeting.
In harmony to the present suggestion, the scoring and image cytometry evaluation using immunohistochemistry
of Cyclin D1 protein
marker stated that the variations
of protein expression in tissue sections could yield
prognostic information or could be useful in determining subtle effects
of curative or prevention therapies [31].
«In the preplanned biomarker analysis, the expression
of pSTAT3 detected by immunohistochemistry was both a
prognostic marker and a predictive biomarker
of benefit from napabucasin,» the researchers wrote.
SO, they had suggested the inhibition
of cyclin Dl / CDK4 activity might be important in considering drugs
of future therapies [25], also, they reported that Cyclin D1 was considered as a significant
prognostic marker.
Floryne Buishand, 30, from the Netherlands, is a postdoctoral researcher at the National Cancer Institute / NIH, Bethesda, USA, studies genomic changes associated with endocrine cancers with the ultimate goal
of identifying novel diagnostic and
prognostic markers, as well as novel therapeutic targets.
Image cytometry
of Cyclin D1: a
prognostic marker for head and neck squamous cell carcinomas.
Although there is currently no technology that allows early diagnosis
of the disease, a number
of putative
markers have been identified: their detection after diagnosis would be a useful tool to monitor the evolution
of the tumor during treatment, providing valuable
prognostic information on response to a given therapy.
Using clinical samples we would like to create an immunoprofile
of activated B cells and memory B cells that may provide
prognostic markers for dengue immunity and / or immunopathology.
We can envision that DAXX can serve as a precise
prognostic marker in PCa and that tissue - specific shRNA delivery targeted against DAXX can be employed in the treatment
of metastatic prostate cancer in patients, in particular if we discover, through additional studies, that DAXX is a
marker for lethal PCa in humans.
We conducted a meta - analysis in nonmetastatic breast cancer patients treated by neoadjuvant chemotherapy (NCT) to assess the clinical validity
of circulating tumor cell (CTC) detection as a
prognostic marker.
Since both ALI and CRP are
markers of inflammation, the aim
of this study was to examine whether the combination
of ALI and CRP is a
prognostic indicator
of resected NSCLC or not.
Known and novel independent
prognostic markers were identified in our cohort
of proteasome inhibitor and IMiD - treated patients with long follow - up, including events with context - specific
prognostic value, such as deletions
of the PRDM1 gene.
The cytotoxicities
of IMGN632 and X-ADC were first assessed in a panel
of AML cell lines, which expressed CD123 at levels similar to AML blast cells (ABC values, 1100 - 13000) and encompassed a variety
of poor
prognostic markers (Table 1).
A randomized pilot trial
of oral branched - chain amino acids in early cirrhosis: validation using
prognostic markers for pre-liver transplant status.