Sentences with phrase «programmed cell death protein»

Italian and American researchers report that the PD - 1 (programmed cell death protein 1) / PD - L1 (ligand 1) axis is a key player in immune surveillance in hematologic malignances.

Checkpoint inhibitors are monoclonal antibodies that target certain proteins that downregulate the immune system, such as programmed cell death protein 1 (PD - 1), programmed death - ligand 1 (PD - L1) and cytotoxic T - lymphocyte antigen 4 (CTLA - 4).

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

One difference that is clear is that exhausted T cells express the programmed cell death protein - 1 (PD - 1), which commands them not to attack normal, healthy cells, but can also prevent them from striking at cancerous or chronically infected cells.

Not exact matches

Rather, the group speculates that the transplanted cells secreted protective neurotrophins, proteins that promote cell survival by keeping neurons from inducing apoptosis (programmed cell death).

In patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.»

The Caenorhabditis elegans Bcl - 2 — like protein CED - 9 prevents programmed cell death by antagonizing the Apaf - 1 — like cell - death activator CED - 4.

By measuring changes in the levels of proteins that control each cell death program and by observing the cells» physical changes, the team saw clearly that cocaine causes neuronal cell death through out - of - control autophagy.

Programmed - death ligand 1 (PD - L1) is a protein that tells the immune system not to kill a particular cell.

In a second study presented at the ESMO 2014 Congress, researchers report that about 20 % of patients with malignant pleural mesothelioma have cancer cells that express a protein called programmed cell - death ligand 1 (PD - L1) that is associated with poorer outcomes.

The Bag1 gene, for example, codes for a protein that in humans is involved in inhibiting an essential natural process called «programmed cell death.»

Previous studies show that antibody treatments that inhibit the protein, called programmed cell death 1 (PD - 1), can shrink tumors in humans.

In the sensitive tumor models, the ability of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.

They kill cells by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis (programmed cell death).

In this case, the trigger is a drug that interacts with the protein produced by the «suicide gene,» which metabolizes it into a form deadly to the cell, causing it to commit programmed cell death (apoptosis).

T - Cell Enzyme Uses Deadly Multipronged Attack on Bacteria — GEN News Paper: Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program — Farokh Dotiwala — Cell

For example, new combinations of domains in death-fold domain proteins and laminins possibly allow for the modification of protein interactions and pathways involved in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functions.

A tomato 14 -3-3 protein (TFT7) positively regulates immunity - associated programmed cell death mediated by diverse disease resistance proteins

It was already known that TAK1 activates two proteins that play a role in immunity, inflammation, programmed cell death and cancer.