Sentences with phrase «programming of the human cell»

It ensures the programming of the human cell upon infection.

Not exact matches

Before we established in - house human taste cell (HTC) technologies, it was not possible to use human tongue - derived cells as a model, due to the lack of homogenous, proliferating cell lines with defined properties, which is a prerequisite to establish comprehensive research and screening programs.

Thousands of people, disproportionately Black and Brown people, remain in solitary in New York each day: 22 to 24 hours a day in a cell without any meaningful human contact or programs.

Funding for this research came, in part, from the National Institutes of Health (1R01NS091010 - 01, 1R01DC014690 - 01), Japan Science and Technology Agency (PRESTO), Pew Charitable Trusts, Alfred P. Sloan Foundation, David & Lucile Packard Foundation, Human Frontier Science Program, McKnight Foundation and New York Stem Cell Foundation.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

«The discovery of the microbiome and its significance represents a huge paradigm shift in our understanding of human health — there are more microbes living on us and in us than our own cells,» said Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Science.

John Glass, a senior microbiologist in the synthetic biology group at the J. Craig Venter Institute in Rockville, Maryland, puts it this way: If you can imagine a set of genes that will program a cell to do something — anything — then you can make them «at a reasonable cost and test your hypothesis... so it will be possible to attempt to design organisms that have extraordinary properties to solve human needs.»

Humans share the same genetic material: the same genetic program resides in each of our cells.

Programmed cell death, or apoptosis, is a natural process that kills billions of cells in a typical human body each day.

«He identified a type of molecular sensor, which programmed T cells isolated from human blood with customized instructions for thwarting attack.

Now scientists in the laboratory of Jan Karlseder, a professor in Salk's Molecular and Cell Biology Laboratory and holder of the Donald and Darlene Shiley Chair, report the first experimental induction of an ALT telomere - building program in human cells.

Dr. Lundberg is currently the director of the Cell Atlas, part of the Swedish Human Protein Atlas program, and an elected member of the executive committee of the Human Proteome Organization.

«We challenged a current dogma in the field that emphasized PLK1's role in mitosis (cell division) as a primary mechanism for cancer growth,» says Zheng Fu, Ph.D., lead investigator on the study, member of the Cancer Molecular Genetics research program at VCU Massey Cancer Center and assistant professor in the Department of Human and Molecular Genetics at the VCU School of Medicine.

«This study adds to an important body of work that has shown the ubiquity of a circadian clock across species, including humans, and its role in metabolic regulation in cells, organs, and organisms,» said Dr. Michael Sesma, Program Director in the Division of Genetics and Developmental Biology at the of the National Institutes of Health's National Institute of General Medical Sciences, which partially funded the research.

A new technique — called DNA Programmed Assembly of Cells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

The new technique — called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

From that an entire human being of some 10 trillion cells is programmed.

«Making the movements of HIV visible so that we can follow, in real time, how surface proteins on the virus behave will hopefully tell us what we need to know to prevent fusion with human cells — if you can prevent viral entry of HIV into immune cells, you have won,» says Dr. Blanchard, who is also associate director of Weill Cornell's chemical biology program.

University of Michigan, Ann Arbor, stem cell researcher Sean Morrison, an outspoken proponent of allowing research on human embryonic stem cells (hESCs) in the state, has been wooed to Texas by its $ 3 billion state cancer research program.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Weian Zhao, associate professor of pharmaceutical sciences, and colleagues have programmed human bone marrow stem cells to identify the unique physical properties of cancerous tissue.

The first step of our program is to apply the previously established lab - culture conditions that first commit human ES (hES) and iPS cells into retinal precursors.

INGESTEM, the national infrastructure in biology and health certified by the «Investissements d'Avenir» program and the Ile - de-France Region (DIM Biothérapies), is the first French network of therapeutic innovations based on pluripotent stem cells, human tissue engineering and their biomedical applications.

«These are very promising findings and, as the first study to demonstrate protection from Zika in the pregnancy setting, are an important development in our efforts to combat Zika virus,» said Michael Diamond, M.D., Ph.D., Professor, Departments of Medicine, Molecular Microbiology, Pathology & Immunology, and Associate Director, Center for Human Immunology and Immunotherapy Program at Washington University School of Medicine, and a lead author on the Cell paper.

Large - scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming.

Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability and schizophrenia.

The research at MIT was funded by Jerry and Marge Burnett, the Defense Advanced Research Projects Agency, the Human Frontiers Science Program, the IET A. F. Harvey Prize, the Janet and Sheldon Razin ’59 Fellowship of the MIT McGovern Institute, the New York Stem Cell Foundation - Robertson Investigator Award, the National Institutes of Health, the National Science Foundation, and the Wallace H. Coulter Foundation.

Zena Werb, University of California, San Francisco, USA Single - cell analysis reveals a stem - cell program in human metastatic breast cancer cells.

By: Sadhana Agarwal, Katherine L. Holton, Robert Lanza Differentiation of human embryonic stem cells (hESCs) to specific functional cell types can be achieved using methods that mimic in vivo embryonic developmental programs.

Health and Medicine Reporter Research Aliquots American Heart Association cell and developmental biology cell division contractile ring Human Frontier Science Program Journal of Cell Biology kathleen gould lipid NIGMS NIH Reporter Nov 10 cell and developmental biology cell division contractile ring Human Frontier Science Program Journal of Cell Biology kathleen gould lipid NIGMS NIH Reporter Nov 10 cell division contractile ring Human Frontier Science Program Journal of Cell Biology kathleen gould lipid NIGMS NIH Reporter Nov 10 Cell Biology kathleen gould lipid NIGMS NIH Reporter Nov 10 2017

Recent Scientific projects as principal investigator: • 2003/2005 (EU V Frame Program): «International Bank of DNA, cell lines and nerve - muscle - cardiac tissues» - «European Network of Human Biological Material for Rare Diseases - Eurobiobank».

In MMEJ pathway, we achieve efficient gene disruption in human cell lines and animals by developing a computer program that assists the choice of nuclease target sites based on microhomology prediction.

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

Scientific programs include: human genomic sequencing and analysis, synthetic genomics and exploration of new vaccines using this technology, and environmental and single cell genomics to explore the vast unseen world of microbes living in the human body, the ocean, soil and air.

The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cHuman Protein Atlas portal with expression profiles of human proteins in tissues and chuman proteins in tissues and cells.

The Swedish part of the effort, called the Human Developmental Cell Atlas (HDCA) program, includes researchers from Karolinska Institutet, Stockholm University and KTH, focusing on brain, lung, heart and fetal development during the first 12 -LSB-...]

Human Research Program (Biochemical Profile and Repository): A 53S crewmember collected blood and urine samples for his FD120 sessions of the Biochem Profile, Repository and Cell Free Epigenome investigations.

George Daley, MD, PhD, professor of hematology / oncology and director of the Stem Cell Transplantation Program at Boston Children's Hospital, says, «By confronting and ultimately solving the many regulatory challenges of a first - in - human trial, Dr. Takahashi has paved the way for all of us in the stem cell community to recognize the promise of iPS cells.&raCell Transplantation Program at Boston Children's Hospital, says, «By confronting and ultimately solving the many regulatory challenges of a first - in - human trial, Dr. Takahashi has paved the way for all of us in the stem cell community to recognize the promise of iPS cells.&racell community to recognize the promise of iPS cells.»

He is the principal investigator of an NCI - funded, multi-million-dollar Specialized Program of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in paProgram of Research Excellence (SPORE) in ovarian cancer, and he is the principal investigator of a multi-million-dollar grant from the New York State Stem Cell Science program (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in paprogram (NYSTEM) to pioneer a novel strategy of reprogramming human mature T cells and hematopoietic stem cells for generating sustained attack against ovarian cancer in patients.

Prof Aviv Regev, co-chair of the HCA Organising Committee, a core member, chair of faculty, and director of the Klarman Cell Observatory and Cell Circuits Program at the Broad Institute of MIT and Harvard; an HHMI Investigator; and Professor of Biology at Massachusetts Institute of Technology, said: «The Human Cell Atlas initiative is growing fast, and with more than 480 scientists now registered with the initiative from 44 countries around the world, it is a truly global collaboration.

2/20/2007 Seven at UC San Diego Receive Stem Cell Funding from California Institute for Regenerative Medicine (CIRM) Dr. Leon Thal of UC San Diego honored with naming of statewide SEED grants More than two years after voters approved a $ 3 billion program to fund stem cell research in California, the state has approved the first grants focused solely on human embr... MorCell Funding from California Institute for Regenerative Medicine (CIRM) Dr. Leon Thal of UC San Diego honored with naming of statewide SEED grants More than two years after voters approved a $ 3 billion program to fund stem cell research in California, the state has approved the first grants focused solely on human embr... Morcell research in California, the state has approved the first grants focused solely on human embr... More...

«The discovery of the microbiome and its significance represents a huge paradigm shift in our understanding of human health» there are more microbes living on us and in us than our own cells,» said Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Science.

U.S. Military HIV Research Program (MHRP) researchers, however, have demonstrated that essentially all of the infectious virus particles can bind to the surface of red blood cells isolated from each of 30 normal (non-infected) human donors.

This approach provides a powerful platform for the generation of human cell types by forward programming.

Programmed cell death is essential in organ development and tissue homeostasis and its deregulation is associated with the development of several diseases in mice and humans.

«Despite clear potential benefits for individuals with T1D, research into human alpha cell dysfunction within the context of T1D has been underappreciated and underfunded,» said Dr. Ben Williams, Program Officer of Helmsley's Type 1 Diabetes Program.

The program offers intensive courses in human embryology, cell biology, human gross anatomy, and medical neuroscience, all of which are equivalent to first - year medical school courses.

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More specifically, epigenetic programming of cells would allow them to show more pronounced inflammatory responses when exposed to challenge (Miller et al., 2011a), an effect that has been observed in primate models (Cole et al., 2012), as well as in humans (Irwin and Cole, 2011).