Sentences with phrase «progranulin brain levels»
Instead of effect sizes of 100 % for proganulin levels, we ask you to provide effect sizes of 20 - 30 % change for power calculations in progranulin brain levels for Figure 3 to determine whether the power value is > 0.70.
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Our study demonstrates that progranulin deficiency may promote Alzheimer's disease, with decreased levels rendering the brain vulnerable to amyloid - beta toxicity.»
When progranulin levels are low, brain cells die more readily when exposed to toxins.
The team, led by Li and her postdoctoral fellow S. Sakura Minami, PhD, showed that low levels of progranulin in the brain lead to symptoms that mimic AD in mice.
SAN FRANCISCO, CA — Researchers at the Gladstone Institutes have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid - beta plaques (a hallmark of Alzheimer's disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition.
Brain progranulin protein levels were measured in all cases by ELISA, and plasma progranulin protein was measured by western blot.
To test the hypothesis that exercise could increase brain progranulin levels in Grn + / − mice, we solo - housed 6 - month - old wild - type (Grn + / +), Grn + / −, and Grn − / − mice in standard mouse cages or cages with running wheels for 7.5 weeks.
Greater running distance in the 2 - to 3 - month - old mice may partially explain these data, but the solo - housed wild - type mice used to test solo - versus group - housing (Fig. 5) ran similar distances as the young mice, yet did not show any increase in brain progranulin levels.
Because the SD of brain progranulin in wild - type mice was about 10 % of the mean level, progranulin levels in Grn + / − mice would need to increase from 50 % of normal to 80 % of normal, i.e. by 30 % of the normal value, to reach the lower limit of normal.
Only Grn + / − mice were included in this group because the primary goal of this experiment was to determine if exercise were capable of increasing brain progranulin levels in Grn + / − mice.
This study does not support the idea of exercise as a strategy to raise brain progranulin levels in symptomatic patients with FTD due to GRN mutations, as we observed no effects on progranulin levels in Grn + / − mice at 4 — 8 months of age, the age range in which these mice begin to develop abnormal behavior and neuronal dysfunction (Filiano et al., 2013).
We housed wild - type and progranulin - insufficient mice in standard cages or cages with exercise wheels for 4 or 7.5 weeks, and then measured brain and plasma progranulin levels.