Sentences with phrase «progression of the disorder»

A few drugs have shown promise in cell culture or animal models, but clinical trials in humans are time consuming because of the slow onset and progression of the disorder's clinical symptoms.

«This study is exciting because it shows that changes within the body can affect the progression of a disorder caused by a genetic mutation,» said Jim I. Koenig, Ph.D., program director at NINDS.

These measures will not reverse or stop the progression of the disorder but it may slow the development of additional symptoms for a time.

In order to reduce the symptoms and slow the progression of the disorder, the patient may need to be placed on a diet restricted to low - fat, high - fiber foods until any inflammation has gone down.

Not exact matches

It was during this time that Dr. Chandra came to appreciate the role of environmental toxins, chronic infections, and nutritional deficiencies in the development and progression of many disorders, including some chronic psychiatric conditions.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

The findings add to a growing body of evidence that protecting or boosting neurotrophins — the molecules that support the survival and function of nerve cells — may slow the progression of Huntington's disease and other neurodegenerative disorders.

«If our hypothesis is correct that Parkinson's is really a calcium - regulation disorder,» Surmeier says, «then stopping that process... should stop the progression of the disease.»

Johns Hopkins physicians report success in a small study of a modified skin biopsy that hastens the earlier diagnosis of an inherited and progressively fatal nerve disease and seems to offer a clearer view of the disorder's severity and progression.

Researchers at Stanford University School of Medicine have identified several new biological markers to measure the progression of the inherited neurodegenerative disorder Huntington's disease (HD).

Current guidelines recommend, depending on a patient's risk score, lifelong monitoring of people with MGUS to detect progression to MM or related disorders, according to the study background.

Means notes that identifying the potential role of TREML4 in human lupus may lead to the development of drugs that could prevent or reduce the development or progression of lupus and another autoimmune disorder called Sjögren's syndrome, which also appears to involve TLR7 overactivation.

With this noninvasive method, researchers may be able to follow the progression of many brain disorders, including epilepsy and Alzheimer's disease, by measuring changes in synaptic density over time.

New research by investigators at the University of Massachusetts Medical School suggests the immune system plays an unsuspected and surprising role in the progression of Rett syndrome, a severe neurological disorder affecting children.

There is currently no cure for this kind of neuromuscular disorder so new treatments that can tackle the progression of disease are urgently needed.»

Because most cases of Parkinson's disease appear to be at least partially caused by environmental factors such as pesticide exposure, these findings support the approach that targeting α - synuclein could slow or stop the progression of Parkinson's in most people with the disease, said study lead author Jeff Bronstein, a professor of neurology and director of movement disorders at the David Geffen School of Medicine at UCLA.

Virtually all mental health disorders come with difficulties in interpersonal relations that in the long run negatively affect the progression of the disease.

«Drug trial shows promise for deadly neurological disorder: Cyclodextrin slows progression of Niemann - Pick type C.» ScienceDaily.

The HALT - PKD trial enrolled volunteers to test whether a combination of commonly used FDA - approved drugs, lisinopril and telmisartan, could shrink kidney cysts and therefore slow progression of ADPKD, a genetic disorder characterized by growth of fluid - filled cysts in the kidneys.

It may also prevent the progression of a vulnerability to later obsessive - compulsive disorder or depression as well as other disorders,» says Moritz.

Neurological disorders such as Parkinson's disease, where there are no objective measures of disease progression, is another area where in silico medicine could be used in a trial setting to test the effectiveness of new treatments.

New research by Vladimir Litvak, PhD, assistant professor of microbiology & physiological systems, suggests the immune system plays an unsuspected and surprising role in the progression of Rett syndrome, a severe neurological disorder affecting children.

Her aim is to understand, at the molecular level, the mechanisms that control communication between the brain, immune system, and blood vessels — with the ultimate goal of designing new therapies that slow, stop, or reverse the progression of a wide range of neurological disorders, such as MS. Recently, Dr. Akassoglou's lab identified how microglia — a type of immune cell that acts as the brain's first line of defense — are activated when fibrinogen enters the brain or spinal cord.

Understanding these hereditary and interrelated disorders will require better in vitro liver models that capture important physiological features of disease progression.

His research interests are focused on the molecular genetics of the inherited myopathies and neuromuscular junction disorders and the study of animal models of these disorders as a means to understand their pathophysiology as well as to develop means to monitor disease progression and therapeutic interventions.

Researchers have developed a new technique that allows them to screen for genes that could contribute to the progression of Huntington's disease and other neurodegenerative disorders.

I harness these technological advancements to assemble genomes for a variety of organisms and probe the genetic basis of neurological disorders, including autism and schizophrenia, better understand cancer progression and understand the complex structures of the genomes of higher plants.

No approved drugs exist to even slow the progression of this relentless disorder.

Thus, RAGE may be a key factor in the progression of long - term brain disorders after sepsis.

He aims to gain a better understanding of the mechanisms that control memory formation in neurons to discover crucial insights into the development and progression of neurodegenerative diseases — and the memory disorders that often characterize them.

ApoE as a major causative factor and therapeutic target in Alzheimer's disease and other neurodegenerative disorders; small - molecule structure correctors to convert apoE4 to apoE3 and reverse the detrimental effects of apoE4 on mitochondria and the cytoskeleton; small - molecule protease inhibitors to block the formation of toxic fragments of apoE4; Plasma lipoprotein metabolism regulation involving apoE and apoB; cholesterol homeostasis modulation by lipoprotein receptors controlling lipoprotein clearance by the liver; Plasma HDL cholesterol (HDL - C) metabolism in the progression of atherosclerosis; the genetic epidemiology of the metabolic syndrome and low HDL - C levels established by the Turkish Heart Study.

Ongoing work: Led by Dr. Fasano, MIBRC researchers are looking at how qualitative or quantitative defects in the regulation of the immune system and the role of dysbiosis can lead to the onset and progression of celiac disease and other autoimmune disorders.

When mice with progressive demyelinating disorders of the peripheral nervous system were put on an alternate - day fasting diet regime, hampered disease progression was observed as indicated by improved nerve morphology and performance compared to mice fed ad libitum (37).

The advanced glycation end products and lipid peroxidation products are ubiquitous to diabetes and Alzheimer's disease and serve as markers of disease progression in both disorders.

For example, alterations in the population of intestinal bacteria of the Lactobacillus group are thought to play a role in the development and progression of several neurological disorders, including anxiety / depression, autism, multiple sclerosis and Alzheimer's disease.

Good nutrition definitely supports good health, and a proactive approach to health (i.e. quality food, regular veterinary visits, regular exercise) certainly helps prevent some disorders, but it also helps slow the progression of certain diseases.

The prognosis for this disorder depends on the severity and progression of disease within the individual animal.

Early detection of many disorders can facilitate their cure or delay their progression.

Social cognition critically impacts the development, progression, and treatment of psychiatric disorders.

Dysfunctional social cognition represents a central characteristic of various psychiatric disorders and critically impacts the development, progression, and treatment of psychiatric illnesses (1 ⇓ — 3).

Developmental emergence of alcohol use disorder symptoms and their potential as early indicators for progression to alcohol dependence

That means that you set the pace for your progression, with the assistance of a professional eating disorder specialist.

An examination of the predictive associations of individual disorders in developed countries revealed that depression is among the strongest predictors of suicide ideation (OR = 3.3), but is much less powerful in predicting progression from ideation to plans (OR = 1.5), planned attempts (OR = 1.5), or unplanned attempts among ideators (OR = 1.2).