Not exact matches
Most
of the studies have focused mainly on
tumour cells, whilst the
cells that form the stroma are the great unknown, in spite
of different research groups proving that some components
of stroma promote the
tumour progression.
We believe that each dog breed may correspond to one type
of B - or T -
cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type
of tumour develops, and how its
progression is regulated», says Ingegerd Elvers.
Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target
of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with
cell growth,
cell cycle
progression and antioxidant machinery [3].
Senescent
cells may promote
tumour progression through the activation
of a senescence - associated secretory phenotype (SASP), whether these
cells are capable
of initiating tumourigenesis in vivo is not known.