Beside the known effects on brain pathology, Doxy also normalizes the expression of different pro-inflammatory markers in the mouse brain, which could be in connection to
progressive brain atrophy.
CLPB mutations cause 3 - methylglutaconic aciduria,
progressive brain atrophy, intellectual disability, congenital neutropenia, cataracts, movement disorder.
Not exact matches
CREBBP has also been associated with Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease, a neurodegenerative disease with
progressive degeneration of motor neurons in the
brain and spinal cord, Alzheimer's disease and poly glutamine repeat diseases such as Spinal and Bulbar Muscular
Atrophy and Huntington's disease.
Corticobasal degeneration is a
progressive neurological disorder characterized by nerve cell loss and
atrophy (shrinkage) of various regions of the
brain, including the cerebral cortex and the basal ganglia (which helps to start and control movements, as well as other functions).
The mice develop neurobrillary pathology already at an age of 2,5 to 3 months, and show
progressive gross
brain atrophy and significant neuronal loss in hippocampal structures.
The latter could be caused by the former, but also by other conditions such as
progressive supranuclear palsy (a rare
brain disorder that destroys nerve cells) or multiple system
atrophy (a degenerative condition originating in parts of the
brain).
Prone to hives caused by stress or insect bites, cerebellar ataxia - an undefined problem in the part of the
brain that controls coordination, PRA (
Progressive retinal
atrophy)- gradual deterioration of the retina beginning with night blindness and eventually total blindness, allergies, cancer, heart problems, socialization issues, training and hip dysplasia, thyroid problems