Sentences with phrase «promising clinical target»

«While the road to heparanase - targeting clinical drugs is long and fraught with risks, with this work we believe to have taken a major step in realising the therapeutic potential of this promising clinical target.»

Not exact matches

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

Whereas some of the other types of visual prostheses propose stimulating different areas of the brain from the one Pezaris is targeting, another promising project known as the Argus II Retinal Prosthesis System is expanding its U.S. clinical trial into Europe.

As promising new therapies such as those directly targeting survivor motor neuron (SMN) are entering clinical trials for infants, children, and adults with SMA, researchers are searching for biomarkers in blood that can monitor their effectiveness.

These results not only show promise on a new targeted therapy to treat this malignancy, as PI3K inhibitors are already used in the clinical practice, but also unravel a new function of the PI3K kinase in cancer biology through its role in promoting metastasis.

The probes targeted to breast cancer have shown great promise so far in breast cancer clinical trials, and Mankoff and his Penn Medicine colleagues have helped lead this research effort.

«Anti-cancer agents that target the protein BCL - 2, which is closely related to MCL - 1, are already showing promise in clinical trials, including some held in Melbourne.

The authors, who are now planning to begin clinical trials based on this study, state that the three enzymes can be promising therapeutic targets for a diverse and broad group of DLBCL patients.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

A new drug that targets not only common cancer - causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I / II clinical trial.

Further study in clinical trials is necessary, but the study provides a promising new find in a type of cancer with no current targeted options, Chan said.

The targeted therapy rucaparib, which has demonstrated robust clinical activity in ovarian cancer patients with a BRCA mutation, also showed promise in previously treated pancreatic cancer patients with the mutation, according to results from a phase II clinical study.

The companies will use the Clinical Genome Miner ™, which combines genealogical, genotypic and disease data, to develop more detailed understanding of the role of Merck targets in the human biology of obesity, and to establish which targets offer the most promising avenues for the development of new drugs.

«Gaining familiarity with the molecular players in a behavior — as this new tool promises — may someday lead to clinical interventions targeting dysfunctional brain states.»

Recently, human clinical trials began for a new pharmaceutical therapy that shows promise for directly targeting and effectively «silencing» the offending genetic mutation responsible for this disease.

A promising new clinical tool and research on targeting a genetic mutation common in oesophageal cancer have been recognised in the 2016 Picchi Awards For Excellence in Cancer Research.

Melanoma has long been considered a promising target for immunotherapy and has been a major focus of immunotherapy clinical development efforts.

Combine that with huge profit - seeking pharmaceutical corporations, fly - by - night supplement companies that have active lawsuits being filed against them for fraud, millions of dollars in advertising and promotions on TV and the internet targeting vulnerable people, and endless layers of websites full of contradictory information about scientific trials, clinical tests, and potentially bogus health promises, and it's no wonder why people end up confused and frustrated.