Sentences with phrase «promising compounds»

Drug development typically begins with a screening that tests the effects of promising compounds on two - dimensional cell cultures.

Several other venture - backed companies such as Juno Therapeutics are developing other promising compounds in this space.

The six - membered ring N - methyl analogue 81 was the most promising compound with an IC50 value of 19 nM.

Notably, VF had promised compounded sales growth of 8 % a year, but delivered only 6 %.

The scientists ruled out caffeine and nicotine as the protective substances, but there are other promising compounds in coffee and tobacco, which the researchers intend to test in these short - lived creatures.

However, attempts to identify promising compounds efficiently and systematically have been stymied by a dearth of well - characterized libraries of repurposing candidates.

The threat of future nerve agent attacks is spurring urgent efforts to find better countermeasures, with several promising compounds in the pipeline.

«It used to be that researchers were lucky if they could identify one or two promising compounds at a time; now with advances in high - throughput screening technology we can explore thousands at once and identify many more,» said Derbyshire, an assistant professor in the Departments of Chemistry and Molecular Genetics and Microbiology at Duke.

The most promising compound improved lens transparency in the R49C cryAA and R120G cryAB mouse models of hereditary cataract.

«This is another example of how our gene discovery work has led us to targets against which promising compounds have been developed by others in other indications.

The most promising compound CHO - V - 52 (racemic) does not activate 5 - HT2A and 5 - HT2B receptors and has an EC50 of 19 nM at the 5 - HT2C receptor.

Seemingly promising compounds emerging from a target - based screen may act quite differently when they're moved from the in vitro environment into a living setting.

The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.

Notably, VF had promised compounded sales growth of 8 % a year, but delivered only 6 % during that period.

To identify promising compounds, the team grew human nerve cells in the lab and tested whether more than 1100 medications, vitamins, dietary supplements, and other molecules altered their output of α - synuclein.

The screening process identified three promising compounds, which were then tested for their ability to prevent Zika infection of human brain cells.

To this end, the U of S has applied for a patent and set up a technology licensing opportunity to invite partners to help develop these promising compounds.

A series of promising compounds can cripple all enveloped viruses» ability to invade cells as well as circumvent any resistance that hobbles traditional antiviral drugs.

Another promising compound, according to Scott Woods of Yale School of Medicine, is D - serine, an amino acid.

In exchange for the data, Lilly gets first right of access for promising compounds.

«No natural medicine in once - promising compound, study of bee health finds.»

Today, preparations are being made to begin phase IIa human trials on this promising compound as a single - dose cure.

To make matters worse, when research institutes license their promising compounds very early in development, the terms of such deals often aren't great for the basic researchers.

«Promising compound could offer new treatment for heart failure.»

The chemical composition of promising compounds can then be identified, the researchers say, by taking the relevant bead and exposing it to a strong oxidising agent.

At this point, we just have a very promising compound.

Additional studies completed recently in Shetty's laboratory have also shown resveratrol as a promising compound for decreasing systemic and brain inflammation, as well as improving cognitive and memory function in animal models of GWI.

The only problem will be ensuring a steady supply of the promising compound without denuding the western Pacific's reefs.

Promising compounds are being generated using established high throughput screening by medicinal chemistry and are being tested in preclinical animal models.

University researchers hope to improve the odds of surviving acute myeloid leukemia by loading a promising compound into nanoparticles that will target the inner recesses of bone marrow where leukemia stem cells lurk.

«Our strong links with industry have enabled us to make great progress by launching this clinical trial of a promising compound that without this partnership may have remained on a shelf gathering dust.»

University of Rochester researchers, working with colleagues at the University at Buffalo, believe they have found a promising compound that could transform the energy storage landscape.

So, promising compounds, multiple beneficial sounding effects, why not?

A non-psychoactive constituent of cannabis, cannabidiol (CBD), is a promising compound in understanding how to put the brakes on microglia.