Sentences with phrase «promising drug targets»

Research yields promising drug targets impacting underlying biology of the disease; Findings form the basis of deCODE's most advanced drug discovery program Reykjavik, ICELAND, July 24, 2002 — deCODE genetics (Nasdaq / Nasdaq Europe: DCGN) today announced the publication...

Additional genes included in the database could be the focus of future drug development efforts because they belong to classes of genes that are thought to make promising drug targets.

Drug companies find themselves unable to reproduce promising drug targets published by the best academic institutions.

This can be done by diet, genetics or drugs, which is why we want to identify promising drug targets.

Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.

Graduate Student Brian Bender helped to determine the first crystal structure of neuropeptide Y. Neuropeptide Y plays a role in the regulation of the hunger feeling and is a promising drug target.

The Nrf2 - ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders.

Not exact matches

When he took office in January, McMahon promised to aggressively target dealers in the borough to help remove drugs from the street.

«Epigenetic alteration a promising new drug target for heroin use disorder.»

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

If it does, he will then study BCCA chemical networks in living cells to determine promising targets for new drugs.

«Research findings may lead to promising Zika virus drug targets.»

The investigators» experiments in mice suggest that the receptors» activation directly aggravates airway constriction and — if the same process is active in people — may be a promising new target for the development of drug therapies.

The logical next step is to develop drugs that target the enzyme, a promise that landed Sherman on the local nightly news talking about the result.

Their findings provide a better understanding of bacterial Beta - glucuronidases and a promising new set of targets for controlling drug - induced GI toxicity.

Eventually the promise of other drug targets, along with the possible side effects of targeting NPY, put a damper on the effort — until now.

«Drugs with multiple targets show promise against myotonic dystrophy type 1.»

New research suggests that the IGF - 1 receptor may be a promising target for arthritis drugs.

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat the most frequent and lethal form of brain cancer, according to a new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

Analysis of Zika virus protease bound to a peptidomimetic inhibitor reveals its catalytic efficiency and promise as a drug target.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

Although more trials are needed before flibanserin could become available commercially, it shows promise as the first drug demonstrated to treat low libido in women — the most common sexual problem in females — by targeting the brain.

While on one hand, there is significant potential in the application of nanoparticles in enhancing heat transfer for tumor ablation and targeted drug delivery, there is also much promise in improving imaging and diagnostic protocols using them.

A new class of experimental drug - like small molecules is showing great promise in targeting a brain enzyme to prevent early memory loss in Alzheimer's disease, according to Northwestern Medicine ® research.

A new drug that targets not only common cancer - causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I / II clinical trial.

«This study, which reveals a potential new drug target to protect mitochondria, is a promising step towards slowing down or stopping the progression of Parkinson's.»

Professor Chris Bunce, Research Director at leukemia & Lymphoma Research, said: «Targeted drugs, like monoclonal antibodies, have shown great promise in recent years in effectively treating a patient's disease while minimising side effects.

Many of these new drugs promise to be more effective because they target key pathways of cancer cells more specifically.

Scientists at the Wyss Institute at Harvard University set out to solve the mystery of how blood flow keeps the vessels intact and, to their surprise, discovered a completely new cell signaling pathway that is a promising target for drugs to treat a variety of debilitating conditions.

Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.

University of California, Berkeley researchers have now found a promising new drug target within that pathway that is appealing, in part, because it appears to control production of only a few percent of the body's many proteins, those critical to regulating the growth and proliferation of cells.

«We think these gold compounds will be a powerful platform to prepare new tracers, and we're working to improve the system and to identify promising, clinically - relevant drug targets,» he said.

These promising results have already raised the interest of the pharmaceutical industry and led the researchers to patent DGKi as a drug target, as they are keen to explore the issue further, searching for molecules that strongly inhibit DGKi without causing side - effects.

Although doctors have long incorporated personal information like family history into treatment plans, personalized medicine holds the promise of revolutionizing medical care by using knowledge of molecular biology and genetics that will allow more precise diagnoses, better diagnostic tests, greater predictability of disease course, more successful therapies by targeting the right treatments to the right patients, and improved patient safety by selecting drugs and their proper dosage to reduce adverse side effects.

These drugs can hit cancer harder than those targeting only one protein, and look promising for preventing or overcoming drug resistance.

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Regensburg University, both in Germany, and the University of Lisboa, in Portugal, have discovered a promising potential drug target for cystic fibrosis.

After identifying three different types of resistance to a promising investigational lung cancer drug in a phase 1 trial, a team of researchers led by Dana - Farber Cancer Institute scientists say new targeted inhibitors and combinations are urgently needed to stay ahead of tumors» constant and varied molecular shape - shifting.

«Instead of pursuing leads, which is the traditional method, SuFEx click chemistry is about connecting promising drug candidates directly with targets,» says Sharpless.

«While the road to heparanase - targeting clinical drugs is long and fraught with risks, with this work we believe to have taken a major step in realising the therapeutic potential of this promising clinical target.»

While such well - defined drug targets have been harder to identify in other cancers, Simon is optimistic that the rational approach to drug discovery will continue to show promise and invites collaborations with Hutch investigators studying potential anticancer drug targets.

In two advanced lung cancer trials, which we covered, new drugs targeting familiar faulty molecules showed promise.

Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and technologies with high therapeutic potential.

However, the spikes present new binding sites for the human immune response to infection and as such, may present promising new targets for the development of different types of drugs.

The companies will use the Clinical Genome Miner ™, which combines genealogical, genotypic and disease data, to develop more detailed understanding of the role of Merck targets in the human biology of obesity, and to establish which targets offer the most promising avenues for the development of new drugs.

Along with testing existing HDAC inhibitors, another promising avenue is to develop drugs that target one or a few of the dozen histone deacetylases.

Research from the Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a promising new target for future drugs to treat inflammatory bowel diseas...

«The lack of vaccines and drugs for dengue has left the mosquitoes that carry the virus as one of the most promising targets for controlling the disease.

Finding points directly to a promising target for drug development and has already been integrated into the deCODEme ™ genome analysis service

The targeted drug delivery appears to be a very promising strategy for controlling the biodistribution of the cytotoxic agent only on malignant tissues by linking it to tumor - targeting moiety.

The findings suggest that PHGDH may represent a promising target for drug development for ER - negative breast cancer.