Sentences with phrase «promising therapeutic approaches»

It has invested more than $ 450 million in research to date, almost 90 percent for translational research; funded testing of more than 100 therapeutic targets for Parkinson's disease (PD); and has undertaken novel industry partnerships to support early - stage promising therapeutic approaches.

The relative contribution of these two pathways to Alzheimer's risk is not known, says Holtzman, but he and others think that changing a harmful form of ApoE into a less damaging one might prove a promising therapeutic approach.

«Our study suggests that ALDH1A3 is a potentially functional biomarker for mesenchymal glioma stem cells, and that inhibiting that enzyme might offer a promising therapeutic approach for high - grade gliomas that have a mesenchymal signature,» says principal investigator Ichiro Nakano, MD, PhD, associate professor of neurosurgery at the OSUCCC — James.

Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.

This confirms our assumption that the suppression of the aggregation of proteins represents a promising therapeutic approach for a large number of neurodegenerative disorders that are currently still incurable,» says Hartl, summarizing the results of the study.

The inflammation parameters in the transplanted kidneys decreased significantly and renal function in all recipients is excellent,» summarises Marcus Groettrup, adding that these results suggest immunoproteasome inhibition as a promising therapeutic approach to suppress chronic antibody - mediated rejection.

Therefore understanding the dysfunctional molecular pathways that cause mDA axonal degeneration, and targeting these to protect or re-grow mDA axons, may be a promising therapeutic approach for PD.

Not exact matches

The study also reinforces the potential value of brain scans for identifying and understanding schizophrenia in individual patients, for finding promising new therapeutic approaches, and for helping clinicians track a patient's progress during therapy.

Clinical trials will be required to establish whether these promising findings will translate into a new therapeutic approach for ALL.

«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.

A new therapeutic approach tested by a team from Maisonneuve - Rosemont Hospital (CIUSSS - EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.

The study, published September 7 in Nature Medicine, provides promise for a new therapeutic approach to treating the millions of people suffering from muscle diseases, including those with muscular dystrophies and muscle wasting associated with cancer and aging.

She added that while investigators are not sure yet how therapeutic approaches would be implemented, having the understanding of how to identify olfactory cues and use the information as part of exposure - based therapy sessions is extremely promising.

Our proprietary TheraT ® and Vaxwave ® platforms have shown promising abilities to elicit high neutralizing antibody responses, but also necessary levels of T cell responses, currently missing in most vaccine and therapeutic approaches.

Genomic engineering as a promising cancer therapeutic approach has experienced a tremendous surge since the discovery of the adaptive bacterial immune defense system «CRISPR» and its potential as a gene editing tool over a decade ago.

These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.

As recently as two years ago, there was little evidence of any academic or biotech industry interest in pursuing clearance of AS as a therapeutic approach to PD, LBD, or other synucleinopathies of aging: after a promising 2005 report, [31] there had been virtual silence.

The objectives to achieve within the 4 years of the NAREB project are: 1 / to select antibacterial molecules and design nanocarriers with strong antibacterial activity, 2 / to test in vitro and in vivo the best therapeutic combinations including innovative genomic and bioimaging approaches, 3 / to assess safety, regulatory and production (GLP / GMP) aspects for the most promising nanoformulations, and 4 / to establishing the Clinical Development Plan for the preparatory work for the subsequent clinical testing of the selected nanoformulations.

This novel approach is an alternative to ultrasound, another promising method researchers are studying to get therapeutic agents into the brain.

Detection of immune cell checkpoint and functional markers in the lung TME: The field of cancer immunotherapy continues to expand rapidly over recent years, with promising clinical results by immune checkpoint inhibitors and other therapeutic approaches.