Sentences with phrase «promising therapeutic targets»
Identifying miR - 211 as a possible cause means the microRNA, and the genes it regulates, could be promising therapeutic targets.
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«The LINK - A dependent HIF1 signalizing cascade and the consequent effects on cancer cells implicate LINK - A and LINK - A interacting kinases and receptors as promising therapeutic targets for TNBC.»
Certain compounds that are involved in oxidative stress look like promising therapeutic targets.
The authors, who are now planning to begin clinical trials based on this study, state that the three enzymes can be promising therapeutic targets for a diverse and broad group of DLBCL patients.
turned into 10 years of systematic research to identify the enzyme PLK4 as a promising therapeutic target and develop a small molecule inhibitor to block it,» says Dr. Mak, Director of The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network.
«Interneurons can reroute after spinal cord injuries, which makes them a promising therapeutic target,» said senior author Todd McDevitt, PhD, a senior investigator at Gladstone.
«We believe that the reestablishment of proper cell transport could provide a promising therapeutic target for Huntington's disease, and potentially other neurodegenerative disorders.»
The adhesion molecule CD146 plays a vital role in inflammation and offers a promising therapeutic target for treating inflammatory bowel disease (IBD) as well as preventing colitis - associated colorectal cancer, say scientists.
The inhibition of MMP - 3 may be a promising therapeutic target for human central nervous system disease, including SCI,» notes Dr. Yune.
The diverse role of the SDF - 1 / CXCR4 axis in the pathogenesis of HIV, cancer, and rheumatoid arthritis, has established CXCR4 as a promising therapeutic target.
The results suggest that Smyd3 is a promising therapeutic target for liver and colon cancer.
«Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer»
CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance abuse disorders.
Previous research suggests it could be a promising therapeutic target.
Not exact matches
Given the importance of ATP synthase in fueling the cell, determining the complete structure of the enzyme has been a scientific holy grail, promising to reveal secrets about the ATP machine that could lead to therapeutic target identification and advance understanding of metabolic disease and other cellular pathologies.
«The study suggests certain gut microbiota, including Ruminococcus and Blautia, may be promising targets for future therapeutic strategies to treat metabolic disorders,» Professor Morris said.
«Our research shows that targeting cannabinoid receptors in the periphery with pharmacological inhibitors that do not reach the brain holds promise as a safe therapeutic approach for the treatment of overeating and diet - induced obesity,» said Nicholas V. DiPatrizio, an assistant professor of biomedical sciences in the School of Medicine, who led the research project.
The phosphatases are also promising targets for therapeutic intervention in the treatment of various cancers,» Dr. Varjosalo states.
Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.
Further exploration of the TCA cycle, using metabolomics, may identify novel therapeutic targets for CKD and in turn may help us evaluate the effects of promising interventions.»
«While the road to heparanase - targeting clinical drugs is long and fraught with risks, with this work we believe to have taken a major step in realising the therapeutic potential of this promising clinical target.»
Their results, the researchers conclude, «show that computationally designed proteins have potent anti-viral efficacy in vivo and suggests promise for development of a new class of HA stem - targeted antivirals for both therapeutic and prophylactic protection against seasonal and emerging strains of influenza.»
The patterns of these polymorphic genes and their expression profiles comprise the molecular signatures of unique pathophenotypes, offering the promise of diagnostic, prognostic, and therapeutic specificity; the definition of disease becomes «personalized», as does its specific therapeutic targets.
Through strategic partnerships with industry and nonprofit organizations, we gain access to a portfolio of priority drugs for testing within our expert focus groups, including checkpoint inhibitors, therapeutic vaccines, innate immune stimulants, targeted therapies, and many other promising treatments and technologies with high therapeutic potential.
Dr. Darryl C. De Vivo: «SMA is a grave and life - threatening condition, but it is the genetic disorder that is most promising for therapeutic target identification.»
«SMA is a grave and life - threatening condition, but it is the genetic disorder that is most promising for therapeutic target identification,» said Darryl C. De Vivo, MD, Sidney Carter Professor of Neurology and Pediatrics, and Co-Director of the Center for Motor Neuron Biology and Disease at Columbia University Medical Center.
These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.
Diverse cellular functions and therapeutic implications of Poly (ADP - ribose) family members: promising targets in cancer therapy
Epigenetic dysregulation has been implicated in neurodegenerative disorders, while targeting histone acetylation is a promising therapeutic avenue for PD.
It has invested more than $ 450 million in research to date, almost 90 percent for translational research; funded testing of more than 100 therapeutic targets for Parkinson's disease (PD); and has undertaken novel industry partnerships to support early - stage promising therapeutic approaches.
Therefore understanding the dysfunctional molecular pathways that cause mDA axonal degeneration, and targeting these to protect or re-grow mDA axons, may be a promising therapeutic approach for PD.
Therefore, this complex is a highly promising therapeutic drug target against diabetes, obesity, Wolff - Parkinson - White Syndrome, cancer, and aging.
Targeting the Class IIa histone deacetylase HDAC4 appears to be a promising therapeutic strategy to treat HD.
Together, these data indicate that MELK is a normally non-essential kinase, but is critical for BBC and thus represents a promising selective therapeutic target for the most aggressive subtype of breast cancer.
My laboratory aims to identify, characterize and validate lncRNA - driven pathways active in allergy - driving helper T cells and airway epithelial cells that could hold promise as therapeutic targets in altering the aberrant immune responses underlying asthma.