In the last several years, researchers have identified gene therapies that can
promote optic nerve regeneration.
The project will identify a potential translational approach for
promoting optic nerve regeneration, and also open a new avenue for identifying novel gene targets that can be manipulated to enhance optic nerve regeneration.
Not exact matches
First based on our completed genetic study we will test if pharmacological inhibition of an identified protein via direct eye injection can
promote long distance
optic nerve regeneration or whether, based on strong preliminary data, manipulation of another novel gene can induce such regeneration.
The proposed study aims to investigate two novel approaches for
promoting long distance (ie, eye to brain)
optic nerve regeneration.
Ultimately, our research will help elucidate factors that prevent proper
optic nerve regeneration and guidance, and to find strategies that
promote reconnection of damaged
optic nerves and restore visual functions following
optic nerve damage.