Sentences with phrase «promote tumor cell growth»

In a recent study, senior author and Yale pathology professor Wang Min demonstrated that the tumors release substances called cytokines to attract macrophages, which then secrete growth factors that promote tumor cell growth and proliferation.

Damage occurs when metastatic tumor cells recruit pre-osteoclast cells to the bone and then induce their differentiation into mature bone - degrading cells, which results in the release of proteins from the bone matrix that promote tumor cell growth.

Interleukin 15 (IL - 15) regulates the development, survival, and functions of multiple innate and adaptive immune cells and plays a dual role in promoting both tumor cell growth and antitumor immunity.

Not exact matches

Mogroside V has been found in research to have the ability to inhibit tumor growth in pancreatic cancer by interfering with the rapid dividing of cancer cells, preventing angiogenesis (blood flow to the tumor), and even promoting cancer cell death (10).

Inflammatory breast cancer cells display a triple - negative breast cancer phenotype that lacks the receptors needed to promote tumor growth.

Researchers at the Bellvitge Biomedical Research Institute of Bellvitge, the Catalan Institute of Oncology and the University Hospital of Bellvitge have participated in an international study published in the journal Cancer Cell that describes how exosomes secreted by tumor cells contain protein and microRNA molecules capable of transform neighboring cells into tumoral cells promoting tumor growth.

Women with the KRAS - variant are also more susceptible to triple - negative breast cancer, tumors whose growth is not fueled by the hormones estrogen and progesterone, or by the presence of a particular genetic mutation known as HER2, which promotes cancer cell growth.

They found that NF - κB, a protein complex known to promote tumor growth, may also have the ability to boost the immune system to eliminate cancerous cells before they harm, as well as promote antitumor responses.

But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

However, tumor cells can circumvent this immune defense by establishing a surrounding microenvironment that prevents the infiltration of NK cells and thus promotes tumor survival and growth.

A new study shows that stable microvasculature constitutes a dormant niche for disseminated breast cancer cells, whereas a sprouting neovasculature (green points) promotes breast tumor cell growth.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

If the targeted RNA encodes a tumor suppressor protein, as scientists have found for some, the ultimate effect of the microRNA could be to promote cell — and tumor — growth.

Their study, published in the ACS journal Chemical Research in Toxicology, found that triclosan, as well as another commercial substance called octylphenol, promoted the growth of human breast cancer cells in lab dishes and breast cancer tumors in mice.

Researchers from the Vetmeduni Vienna have now discovered that NK cells can switch and promote tumor growth, with STAT5 acting as the key regulator.

They promote the growth of cancerous cells by releasing growth factors and increasing the response of certain proteins that regulate tumor cell development (oncoproteins).

They found that, by using math models to understand the complex dynamics within cancers, they could use small changes in the environment to promote the growth of cells that are less aggressive and thereby decrease tumor growth.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

Karin's team also suppressed IKKß in myeloid cells, a type of white blood cell that can promote tumor growth.

The scientists in Augustin's laboratory consequently pursued preclinical tumor therapy experiments, which were aimed at not just blocking angiogenesis, but to also suppress the production of tumor - promoting growth factors in endothelial cells.

«We're looking for multiple mutations across tumors, mutations that turn on genes and promote cell growth,» Dias - Santagata says.

A widespread cancer - causing protein called MYC promotes the growth of tumor cells in part by ensuring that RNA transcripts are properly spliced, according to latest work from A * STAR researchers.

These analyses showed that Angiopoietin - 2 is not just affecting angiogenesis, but controls at the same time the production of tumor promoting growth factors in endothelial cells.

Due to the lack of oxygen in the cancer cells, VEGF - A (Vascular Endothelial Growth Factor) is formed and this promotes the formation of new blood vessels to supply the tumor.

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

Scientists have known that LPA is secreted by many types of cancer cells, appears to promote the growth and spread of tumor cells, and that immune cells known as CD - 8 «killer» T cells have several receptors for LPA.

The analysis also found that a significant fraction of tumors contained rearrangements and mutations of a gene called PREX2, and experiments confirmed that cancer - associated mutations of PREX2 promoted the growth of human melanoma cells in mice.

More importantly, Zhang and his team for the first time found that treating the pancreatic tumor cells with MIR506 induced autophagy, a process that occurs as a normal and controlled part of an organism's growth or development and that could promote cancer cell death.

The researchers have shown that this marker protein changes myoepithelial cells in breast tissue to promote tumor cell invasion in vitro and enhances mammary tumor growth in vivo.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Although mutations to the complex, dubbed GATOR1, are prevalent in cancer cells and promote tumor growth, they also render the cells susceptible to treatment with the drug rapamycin.

VEGF normally promotes the growth of endothelial cells, which in turn helps build new blood vessels in tumors.

Immune cells initially inhibit tumor growth; however, tumor cells often suppress not only the tumor - inhibitory function of immune cells, but they can also hijack immune cells to promote tumor growth.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

When breast cancer cells invade the bone microenvironment, they produce molecules that activate osteoclastic bone resorption, leading to the release of growth factors stored in the bone matrix to promote tumor growth.

Several soluble factors released by stromal cells within the bone microenvironment promote tumor growth and survival (27).

We suggest that stromal catabolism, via autophagy and mitophagy, fuels the anabolic growth of tumor cells, promoting tumor progression and metastasis.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

These findings provide evidence that IL - 15 may promote tumor cell progression via CD215 + myeloid cells, and IGF - 1 may be an important candidate that IL - 15 facilitates tumor growth.

Furthermore, we found that human IL - 15 mediated insulin - like growth factor - 1 production in CD215 + myeloid cells and blocking IGF - 1 reduced the tumor - promoting effect of IL - 15.

Some claim that it does promote the growth of breast cancer cells, while others say that it can halt the tumor.

Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage cells and in membranes that line the joints, among them tumor necrosis factor — which destroys joint cartilage — and vascular endothelial growth factor, which promotes excessive growth of blood vessels in inflamed joints.

Interleukin - 8 (IL - 8), a well - known tumor - growth promoting inflammatory cytokine104 is «substantially increased» in a number of different types of cancer cells.105 «We found for the first time that caprylic acid and MCT suppress IL - 8 secretion by Caco - 2 cells [colon cancer cells],» reported Japanese researchers in 2002.106

According to the article, sugar may fuel cancer cells, promoting tumor growth.

But because metformin may stem cancer through several different channels — by lowering insulin, directly slowing tumor growth, or promoting suicide by cancer cells — it could potentially prove useful in many types of cancer.

In Canada and Europe THC has been proven to destroy tumors, prevent Alzheimers, and promote the growth of brain cells.