Sentences with phrase «promoter methylation»
Promoter methylation refers to a chemical modification that can happen to specific regions of our DNA. It involves the addition of a small molecule called a methyl group to the beginning part of a gene. This modification can switch off that particular gene, preventing it from being active and producing proteins. Full definition
Maternal mental well - being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate.
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Epigenetic gene promoter methylation at birth is associated with child's later adiposity.
Second, DRD1 and SLC6A3 genes have higher promoter methylation in the CPA group and increased brain dopamine levels are thought to be positively associated with aggression [20], [89].
An issue of controversy has been whether aberrant promoter methylation in normal tissue may be a cancer risk factor.
MGMT promoter methylation is associated with temozolomide response and prolonged progression - free survival in disseminated cutaneous melanoma.
With the knowledge that the HOXA9 promoter is methylated in stage I tumors, Robles, Lissa, and team used ddPCR technology to analyze HOXA9 promoter methylation in formalin - fixed, paraffin - embedded tumor specimens.
This last observation seems to indicate that promoter methylation does not play a significant role in regulation of gene expression between tissues.
Moreover, using a Bayesian deconvolution method to estimate methylation levels from the data [53], we found promoter methylation levels to be significantly inversely correlated (p value = 2.3e - 25) with previously published gene expression levels of T cells from human samples (Figure S1).
We compared blood CD3 + T cells genome - wide promoter methylation profiles of two groups: adult males who had been shown to be on a CPA trajectory between 6 and 15 years of age and males with the same background who followed a normal physical aggression trajectory (control group)[9], [12].
The distributions show that genes with low or no expression (represented in green) tend to have highly methylated promoters, whereas genes with high expression (represented in red) tend to have lower promoter methylation.
We also used the Ingenuity Pathway Analysis software to determine which, if any, gene functions were significantly enriched with genes whose differential promoter methylation levels were associated with chronic aggression.
On the contrary, the expression level of KLF4 was downregulated in the gastrointestinal cancer due to the promoter methylation, and overexpression of this gene was shown to attenuate the tumorigenicity of colonic and gastric cancer cells in vivo (31, 32).
Previous studies reported that there is a reduction or loss of expression of the APC protein in 40.7 % of primary human breast cancers (Ho et al., 1999), and it appears to be more often due to promoter methylation (36 - 54 %) and loss of heterozygosity (LOH)(23 %) than to somatically acquired APC mutations in human breast cancers (Sarrio et al., 2003, Jin et al., 2001, Banerji et al., 2012, 2012).
These observations suggest that in addition to LOH, promoter methylation, and the APC mutations, miRNAs that target APC may regulate the aberrant activation of the canonical WNT signaling pathway for the initiation of human breast cancers, the enhancement of niche independence, and the aberrant proliferation of the human BCSCs.
Higher RBC folate is associated with more promoter methylation while higher intakes of choline seems to cause less promoter methylation.