Sentences with phrase «promotes tumor invasion»

Our results highlight FN assembly and integrin - αvβ3 expression as new hallmarks of CAFs that promote tumor invasion.

Not exact matches

However, when these myeloid cells migrate to tumor sites, they can differentiate to tumor associated macrophages (TAMs), which can in turn stimulate the formation of blood vessels in tumors and promote enhanced tumor cell invasion and motility.

The researchers have shown that this marker protein changes myoepithelial cells in breast tissue to promote tumor cell invasion in vitro and enhances mammary tumor growth in vivo.

STC2 overexpression could promote tumor cell proliferation, invasion, and metastasis in prostate cancer, ovarian cancer, or neuroblastoma.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Tumors thrive in a low oxygenated environment and this condition known as hypoxia promotes the invasion of cancer and its growth (1).