The authors uncover the
cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by
promoting self - renewing division and inhibiting
differentiation.
Special focus is placed on Rho - kinase inhibition, relating to its potential to
promote and support extracellular matrix production in cultured chondrocytes and its role in fibroblast cells as a part of direct chemical
cellular differentiation.
Over-inhibition of 5AR results in increased availability of testosterone, which may be shunted, via aromatase, to estradiol, causing «feminization,» e.g., gynecomastia, one of the side effects of 5AR inhibitor drugs; and decreased production of not only 5α - DHT, but its metabolites, 5α - Androstane - 3α - 17β - diol (aka 3α - adiol, a storage form of 5α - DHT), and 5α - Androstane - 3β - 17β - diol (aka 3β - adiol), an estrogen receptor beta (ERβ) ligand that
promotes normal
cellular differentiation, thus lessening risk of benign prostatic hypertrophy and prostate cancer.22, 23, 24