The cancer
promoting effects of estrogen on breast tissue are restricted by lignan compounds which bind to estrogen receptors.
Despite strong support for the proliferative and growth -
promoting effects of estrogens on mammary epithelial cells from animal and experimental studies (78, 79), previous studies on the associations between estrogens and breast density showed largely null or inconsistent results.
Not exact matches
Moreover,
estrogen can exert direct
effects on fat tissue by enhancing proliferation
of preadipocytes, especially in females (232), and by up - regulating sc α2A - adrenergic receptors
promoting SAT accumulation, notably in premenopausal women (233).
Over-inhibition
of 5AR results in increased availability
of testosterone, which may be shunted, via aromatase, to estradiol, causing «feminization,» e.g., gynecomastia, one
of the side
effects of 5AR inhibitor drugs; and decreased production
of not only 5α - DHT, but its metabolites, 5α - Androstane - 3α - 17β - diol (aka 3α - adiol, a storage form
of 5α - DHT), and 5α - Androstane - 3β - 17β - diol (aka 3β - adiol), an
estrogen receptor beta (ERβ) ligand that
promotes normal cellular differentiation, thus lessening risk
of benign prostatic hypertrophy and prostate cancer.22, 23, 24
Towards the end
of pregnancy,
estrogen promotes the growth
of milk ducts within the breasts and enhances the
effect of prolactin (the major hormone responsible for lactation in the female).
In other laboratory studies, ellagic acid seems to reduce the
effect of estrogen hormone in women in
promoting growth
of breast cancer cells in tissue cultures.
In addition, I3C inhibits formation
of 4 - hydroxyestrogen, another potent
estrogen possessing growth -
promoting effects that has a strong affinity for
estrogen receptors (43).
While pesticides chemicals have a number
of different
effects on our bodies, one
of the scariest is that they mimic
estrogen; it's like giving us a shot
of female hormones, which undermines our ability to build lean muscle and
promotes fat storage.