Sentences with word «promyelocytic»
The word "promyelocytic" refers to a specific type of cell found in the body called a promyelocyte. These cells are a stage of development in the bone marrow before they mature into white blood cells. Full definition
Activation of both protein kinase A (PKA) type I and PKA type II isozymes is required for retinoid - induced maturation of acute promyelocytic leukemia cells.
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Pagano was diagnosed with acute promyelocytic leukemia in late September.
It reveals that targeted treatments for acute promyelocytic leukaemia, a rare form of blood cancer, cause a cascade of molecular events leading to cellular senescence and recovery.
PML bodies, so named because they were first observed in promyelocytic leukemia tumor cells, are a hallmark of ALT - dependent cancers.
Retinoic acid — induced gene G (RIG - G), a gene originally identified in all - trans retinoic acid — treated NB4 acute promyelocytic leukemia cells, is also induced by IFNα in various hematopoietic and solid tumor cells.
Studies conducted in China and the United States demonstrated that arsenic — long considered a carcinogen — helps treat a blood cancer called acute promyelocytic leukemia.
This understanding of the cellular and molecular mechanism of recovery from acute promyelocytic leukaemia opens prospects for activating this same PML / p53 pathway in other types of cancers.
In the induction stage, patients typically receive a chemotherapeutic drug along with a medication called ATRA, in hopes of rapidly eradicating the promyelocytic white cells.
The news that Indianapolis Colts head coach Chuck Pagano has started chemotherapy for a rare form of cancer known as acute promyelocytic leukemia (APL), while devastating to the team, city, and entire NFL community, comes with a silver lining: under the proper medical care and with a timely diagnosis, it is a treatable condition associated with a favorable prognosis.
These chromosomal translocations are common in various types of leukemia, so the researchers examined two types: acute promyelocytic leukemia, which often carries a translocation between the PML and RARα genes; and acute myeloid leukemia, which can harbor a translocation between the MLL and AF9 genes.
Studying acute promyelocytic leukemia cells under a microscope, the researchers noticed that they become abnormally large in the presence of arsenic.
With arsenic forcing the production of largely useless telomerase in cell lines that simulate acute promyelocytic leukemia, the chromosomes in cancer cells fuse together, causing the cell death that helps fight the cancer.
Now a research team led by investigators in the Cancer Research Institute at Beth Israel Deaconess Medical Center (BIDMC), has identified an inhibitor of the Pin1 enzyme that can address both of these challenges in acute promyelocytic leukemia (APL) and triple negative breast cancer.
ATRA was first discovered for the treatment of acute promyelocytic leukemia (APL) in 1987.
Next, we discuss IL - 4 and IL - 15 involvement in the generation of innate CD8 (+) T cells and particularly its possible dependency on the promyelocytic leukemia zinc - finger factor expressing iNKT cells, an innate T cell subset well documented for its susceptibility to tumor immune subversion.
Exclusion Criteria: • Subject was diagnosed as acute promyelocytic leukemia (APL).
Chen says that arecoline could be compared to arsenic, a form of which is used as a treatment for acute promyelocytic leukemia, but is also linked to several types of cancer.
A Phase III Study for Patients with Newly Diagnosed Acute Promyelocytic Leukemia (APL) using Arsenic Trioxide and All - Trans Retinoic Acid
Extremely Late Extramedullary Relapse of Acute Promyelocytic Leukemia, Case Report and Review of the Literature
Patients with a rare type of leukemia called acute promyelocytic leukemia (APL) have better outcomes than most leukemias because they can be treated with a very...
A combination of all - trans retinoic acid (ATRA) and arsenic trioxide resulted in outcomes «at least not inferior» to those achieved when ATRA was used in combination with idarubicin chemotherapy in newly diagnosed patients with non — high - risk, acute promyelocytic leukemia.
Patients with a rare type of leukemia called acute promyelocytic leukemia (APL) have better outcomes than most leukemias because they can be treated with a very effective drug that converts their cancer cells back to normal.
Arsenic trioxide (ATO) consolidation was well tolerated in pediatric patients with acute promyelocytic leukemia (APL) and allowed for significant reductions in cumulative anthracycline doses, according to the results of the Children's Oncology Group AAML0631 trial published in the Journal of Clinical Oncology.
Arsenic trioxide consolidation was well tolerated in pediatric patients with acute promyelocytic leukemia and allowed for significant reductions in cumulative anthracycline doses.
The retinoic acid — induced gene G (RIG - G), also known as IFN - inducible gene 60, was originally identified in all - trans retinoic acid (ATRA)-- treated NB4 acute promyelocytic leukemia (APL) cells (1) and plays an important role in cell growth inhibition through up - regulation of p21 and p27 (2).
* Acute promyelocytic leukaemia is caused by the modification of two genes, RAR and PML, leading to the development of cancer cells; ** the gene coding for p53 protein plays an essential role in cell proliferation under normal conditions and in maintaining the integrity of the cell genome.
Therapy - induced PML nuclear body re-formation and TP53 activation trigger acute promyelocytic leukemia cure.
The PML / RARA * protein causes the proliferation of cancer cells in patients affected by acute promyelocytic leukaemia.
This is my story as I fight APL (Acute Promyelocytic (M3) Leukemia).
Brian & Sara Fitzgerald (Jason Patric & Cameron Diaz) found out that their eldest daughter Kate was diagnosed acute promyelocytic leukemia at two years old.