Consistent with having a lower temperature tolerance, longfin smelt exhibited
a pronounced cellular stress response, with an upregulation of heat shock proteins, after exposure to 20 °C that was not observed in delta smelt.
In a study published March 29, 2018 in Science, UCSF biochemist Peter Walter, PhD, and structural biologist Adam Frost, MD, PhD, showed that the drug, ISRIB (
pronounced «iz - rib»), acts like a molecular staple, pinning together parts of a much larger protein involved in
cellular stress.