Not exact matches
The idea
of making transgenic drugs occurred to a number
of scientists during the mid-1980s, when the new industry began to wrestle with the challenge
of making complex
proteins: ensuring that these big molecules were folded into the
proper shape and that they had all their sugars in the right places on the surface
of the
proteins» amino acids.
The stickiness holding these «nanorods» together were non-covalent bonds between backbone atoms, the same types
of bonds nature uses so that
proteins take their
proper shapes.
Starting in the late 1980s, their labs revealed steps in how the endoplasmic reticulum, the cell's factory for processing secreted and membrane
proteins, deals with
proteins whose linear sequence
of amino acids hasn't folded into a
proper 3D
shape.
Howard Hughes Medical Institute researchers have discovered that all the necessary information to sculpt a
protein into its
proper shape and function is contained in a relatively simple set
of...
But Hsp90 is also what's called a «chaperone
protein,» a member
of a family
of proteins dedicated to helping fellow
proteins assume their
proper shapes.