«Several lead molecules for
prospective clinical use have been identified through our collaboration with Dr. Kenneth Jacobson at the National Institutes of Health and we are very excited about the potential for translational therapeutic impact,» Salvemini said.
Not exact matches
Besides randomized controlled
clinical trials, there are a number of ways researchers can study how a particular cancer treatment is playing out in the real world: there are retrospective studies, observational studies, and even
prospective research done
using patient registries.
Diamond is also quick to point out that while the current study shows that COXEN could have been
used to predict the most useful drug in many of these cases of advanced ovarian cancer, the actual
use of the model will be possible only after validation with a
prospective clinical trial.
«We studied asymptomatic individuals with a low risk of cardiovascular events at baseline and
used noninvasive imaging to predict the risk of an event downstream,» said David A. Bluemke, M.D, Ph.D., from the National Institutes of Health
Clinical Center in Bethesda, Md. «This is the first population - based
prospective study to determine if vulnerable plaque features by MRI add to the risk of a cardiovascular event beyond the traditional risk factors.»
A 2012 meta - analysis of available literature in the European Journal of
Clinical Nutrition found: «Magnesium supplementation appears to achieve a small but clinically significant reduction in BP, an effect worthy of future
prospective large randomized trials
using solid methodology.»
«To evaluate cause - and - effect relationships between long - term PPI
use and possible effects on cognition in the elderly, randomized,
prospective clinical trials are needed,» said corresponding author Britta Haenisch, from the German Center for Neurodegenerative Diseases in Bonn.
The relatively low prevalence of recorded diagnoses of BOAS and other respiratory problems in the current primary - care population
using a retrospective observational study design is in sharp contrast with the findings from some other
prospective clinical studies.
MAPS plans on
using the money to fund its
prospective phase - III
clinical trials that will cost somewhere around $ 26 million in total.