He's focused on the physiopathology of severe malaria in pregnant women and children, with a special interest in the identification of clinically relevant cytoadhesion phenotypes in P. falciparum and P. vivax, in the host and parasite molecules involved as well as in the targets of
protective immune mechanisms.
Not exact matches
Although the
immune mechanisms implicated in the development of childhood asthma are not fully understood, some studies seem to suggest that the BCG vaccine, used in tuberculosis prevention, may have a
protective effect on childhood asthma.
It is known that the
immune response is important in neurodegeneration, but inflammation can be either
protective or damaging and the exact
mechanisms are still unclear.
The researchers said their findings suggest that drugs influencing this
protective mechanism could be used to alert the
immune system to fight cancers.
«The observed increase in the ratio of cytotoxic CD4 T cells to CD4 helper T cells indicates that they are an important component of the
protective immune response to viral infections and that their induction should be an important marker for successful vaccinations against certain viral diseases,» says postdoctoral researcher and first author Veena Patil, Ph.D. «But we really didn't know enough about their molecular profile and the
mechanisms that drive their differentiation and maintenance.»
«We wanted to learn whether the
mechanisms that allow the body to be tolerant would affect its ability to elicit a
protective immune response when needed.
To identify this
protective mechanism, Nagler and her team studied cellular and molecular
immune responses to bacteria in the gut.