Sentences with phrase «protein amyloid»

Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta.

The drug, bexarotene, was found to reduce levels of the neurotoxic protein amyloid - beta in experimental mice with late - stage Alzheimer's but to increase levels during early stages of disease.

AD is thought to be caused by the abnormal accumulation of a 40 - 42 amino - acid long amyloid - β (Aβ) peptide derived from cleavage of the transmembrane protein amyloid - precursor protein (APP).

Earlier lab work by the researchers helped explain key mechanisms involved with assisting vitamin D3 to clear the abnormal protein amyloid - beta, which is found within the plaque.

In another experiment the researchers gave the nematodes the toxic protein amyloid - beta [Abeta].

The results, published online October 31 in Molecular Psychiatry, suggest that the protein amyloid - beta outside the brain may contribute to the Alzheimer's disease inside it, says Mathias Jucker, a neurobiologist at the University of Tübingen in Germany...

The accumulation of the protein amyloid beta in the brain is a sign of Alzheimer's disease.

The drug also appeared to reduce the amount of the protein amyloid beta (which forms toxic plaques in the brains of Alzheimer's patients) by decreasing the levels of metals such as zinc and copper.

In the lab, protein amyloids, like those that clog up the brains of people who died from Alzheimer's disease, are impervious to just about anything, including extreme heat and cold and powerful detergents.

Washington University scientists found that a lack of sleep could increase the protein amyloid beta, a protein linked to Alzheimer's disease.

This very small study suggests that one night of sleep deprivation can raise levels of the hallmark Alzheimer's protein amyloid, strengthening suggestions that sleep is important for limiting the build - up of this protein in the brain.

They found that participants who slept very little produced more of the protein amyloid beta, which is linked to Alzheimer's.

Plaques made of the protein amyloid were on the outside of cells, and they triggered tangles of a second protein, tau, within neurons — just as they were in the dissected brains of people who had Alzheimer's.

Found that cathepsin B (CatB) degrades the protein amyloid β (Aβ) via a unique catabolic mechanism.

The compound sticks to the free - floating forms of the protein amyloid, which build up into damaging plaques in the brain.

One of the key indicators of Alzheimer's disease are the protein amyloid plaques that form and prevent electrical and chemical signaling between neurons.