Specifically, the mice lacked
the protein ankyrin - G, in particular neurons in the brain, a defect that appears to make the animals both hyperactive and less fearful, a behavioral profile suggestive of a mania - like state for a mouse.
The sequence similarity between MAD - 3 and pp40 includes a casein kinase II and consensus tyrosine phosphorylation site, as well as five repeats of a sequence found in the human erythrocyte
protein ankyrin.
Not exact matches
The active ingredient comprises several DARPins (designed
ankyrin repeat
proteins).
Their collaborators — Paul Jenkins, Ph.D., and Vann Bennett, M.D., Ph.D., then at Duke University Medical Center — had tried creating a mouse mutant completely lacking the
ankyrin - G
protein, but the mice didn't survive because
ankyrin - G seems to be required for nervous system development.
To see what was happening in the brains of these
ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two
proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in
ankyrin - G mutant mice than in normal mice.
I became an eye researcher completely by accident while trying to unravel the role of a
protein called
Ankyrin in forming biological important membrane domains in cells, in this case, the photoreceptor.
Several putative transcripts with homology to chitinase and chitinodextrinase were upregulated in future ocean conditions, as well as two putative transcripts with homology to
ankyrins, and one transcript with homology to an ABC transporter solute - binding
protein (see electronic supplementary material, table S5).