This was made possible by a combination of nuclear magnetic resonance spectroscopy (NMR) and electron paramagnetic resonance spectroscopy (EPR), two procedures that make it possible to characterise the structural configuration of
a protein at atomic resolution.
In 1990, Henderson was the first to use an electron microscope to produce «a three - dimensional image of
a protein at atomic resolution.
Not exact matches
Researchers have gone on to study «
proteins that cause antibiotic resistance» and to produce three - dimensional images of the Zika virus
at atomic resolution, permitting scientists to hunt for weaknesses that new pharmaceuticals could exploit.
«Additionally, while previous studies of dynein have revealed the molecule's two different static conformations, our animation visually depicts one plausible way that the
protein can transition between those shapes
at atomic resolution, which is something that other simulations can't do.
Then in 1990, after 15 years» work refining sample preparation and electron detection, Henderson succeeded in using an electron microscope to create an image of a large bacterial cell membrane
protein called bacteriorhodopsin, and do it
at atomic resolution.
Cryo - electron microscopy fires electrons
at proteins that have been frozen in solution, providing images of such high
resolution that scientists can create models down to the
atomic level.
LiWang's lab also collaborates with X-ray crystallographers like Carrie Partch
at the University of California, Santa Cruz, because X-ray crystallography is a powerful technique to capture static structures of
proteins and their complexes
at atomic and near -
atomic resolution.
Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing
at atomic - level
resolution the structure and assembly of the organelle's
protein shell.
Several more researchers presented their work during the day, including
protein synthesis
at atomic resolution, bio-imaging opportunities
at synchrotrons, multi-dimensional imaging during plant cell differentiation, how to use electron cryomicroscopy for in situ structural biology, and how structured illumination microscopy can offer insights into the regulation of mammalian meiosis.
«Fitzpatrick and colleagues have paved the way for development of new drugs designed to prevent tangle formation by deciphering the molecular structure of the «tau»
protein filaments that make up the tangles
at atomic resolution.
«Seeing this drug bound to its intended human
protein target
at atomic resolution was mind - blowing,» said Frost, an assistant professor of biochemistry and biophysics
at UCSF.