Sentences with phrase «protein changes in the brain»

The cognitive impairments — which affected a large subset, but far from all, of the animals — appear to be linked to protein changes in the brain, the scientists say.

Not exact matches

As they studied brain activity in the knockout mice, the researchers also found prominent changes in a receptor in the brain known as mGluR5 and other proteins that support the function of neurons and synapses, said co-lead author Xiaoming Wang, M.D., Ph.D., senior research associate in Duke's department of pediatrics.

After enough proteins get in on the act, holes begin to form in the brain, causing physiological and behavioral changes.

Prion diseases seem to start with changes in the shape of the prion protein found in mammalian brains, which, mysteriously, prompt other identical prions to change shape too.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

Now, the team has published a new paper that demonstrates how these proteins can be used as tools to regulate the activity of individual neurons in the brain through changes in temperature.

For example, mice have been given an extra color vision gene in the lab, and it has been shown that the protein manufactured by that gene expands the scope of their vision by enhancing their ability to see longer - wavelength light without any other changes in the brain.

Although the researchers do not yet know how disruptions in TOP3B affect brain development, they say the most likely explanation is that it changes the shape of the RNA, and thereby disturbs which RNA molecules get copied into proteins.

That study showed a change in a pre-membrane protein could cause microcephaly; the Nebraska study showed how glycosylation of the envelope protein may contribute to the virus efficiently gaining entry into the brain.

Boulanger was senior author on a 2013 paper in the journal Learning and Memory that found that mice bred to produce less functional MHCI proteins exhibited striking changes in the function of the hippocampus, a part of the brain where some memories are formed, and had severe memory impairments.

When the scientists recently gave mice a single dose of cocaine and looked for signs of autophagy in their brain cells, they detected autophagy - associated proteins and changes in vacuoles in adults and in mouse pups whose mothers had received cocaine while pregnant.

Huntington's disease, for example, is caused by aggregating proteins inside brain neurons that ultimately lead to motor dysfunction, personality changes, depression and dementia, usually progressing rapidly after onset in people's 40s.

Specifically, the release of a stress - coping hormone called corticotropin - releasing factor (CRF), which is widely found in the brain and acts as a neurotransmitter / neuromodulator, is dysregulated in AD and is associated with impaired cognition and with detrimental changes in tau protein and increased production of amyloid - beta — protein fragments that clump together and trigger the neurodegeneration characteristic of AD.

However, the team was able to show that so - called tight junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of expression in the absence of bacteria.

We identified species - specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.

The DNA change may inhibit the buildup of β amyloid, the protein fragment that accumulates in the hallmark plaques that form in the brains of Alzheimer's patients.

«Researchers probe brain disease - causing proteins at the atomic level: A change in a single amino acid determines which species are vulnerable, study finds.»

Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

Over-activation of the inflammatory protein nuclear factor κB (NF - κB) in the brain region leads to a number of aging - related changes in mice, from cognitive decline to muscle weakness.

In the new research, published in Neuron, the scientists found that the apoE4 protein changes the activity of neurons in the hippocampus — an important memory center in the brain that is severely affected by Alzheimer's diseasIn the new research, published in Neuron, the scientists found that the apoE4 protein changes the activity of neurons in the hippocampus — an important memory center in the brain that is severely affected by Alzheimer's diseasin Neuron, the scientists found that the apoE4 protein changes the activity of neurons in the hippocampus — an important memory center in the brain that is severely affected by Alzheimer's diseasin the hippocampus — an important memory center in the brain that is severely affected by Alzheimer's diseasin the brain that is severely affected by Alzheimer's disease.

In another study, those who reported SCI were also more likely to show changes in their brains on imaging scans, specifically demonstrating higher levels of beta - amyloid proteiIn another study, those who reported SCI were also more likely to show changes in their brains on imaging scans, specifically demonstrating higher levels of beta - amyloid proteiin their brains on imaging scans, specifically demonstrating higher levels of beta - amyloid protein.

Changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease.

Following disruption of the normal flora balance, mice became less cautious, and changes in the animals» brain - derived neurotrophic factor — a protein associated with mood disorders — increased significantly.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal neurons; a decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.

This little protein is essential in your brain being able to change, to grow, and to adapt.

Real food contains nutrients like omega 3 fatty acids, zinc etc., which bring about positive changes in a brain protein.

Brain changes: Results from misfolded prion protein that causes a «domino effect» in which prion protein throughout the brain misfolds and thus malfunctBrain changes: Results from misfolded prion protein that causes a «domino effect» in which prion protein throughout the brain misfolds and thus malfunctbrain misfolds and thus malfunctions.

Robust changes in expression of brain - derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma.