Not exact matches
Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown
gene that appears to
code for a
transcription factor — a
protein that switches other
genes on or off.
Transcription - factor
genes code for
proteins that regulate the activity of other
genes and so affect an animal's ability to respond to its environment.
All of these
genes code for
transcription factors, which are
proteins that control the expression of other
genes.
The
gene codes for a type of
protein called a
transcription factor.
The
genes for each
transcription factor were made from different bits of DNA that
code for the functional parts of
proteins, such as a domain that can bind to DNA and another that provides the
protein with access to the cell's nucleus.
The researchers classified pri - miRNAs into three broad categories based on
gene structure: Class I, which are transcribed independently of other
genes and likely represent independent
transcription units, Class II, which are transcribed as an extension of a
protein -
coding gene, and Class III, which are transcribed as an extension of a noncoding RNA.
In fact, they found that TGF - β halts both the
transcription of the p53
gene - the process by which cellular machinery reads the DNA
code for a
gene - and the subsequent process by which the corresponding p53
protein is produced, known as translation.
The DNA of those
genes is folded tightly, and chemicals called methyl groups attach themselves to the
genes, preventing the
transcription of genetic
code that enables the
proteins associated with the
genes to form.
Since the two most reliable estimates based on cloned material vary from 11,000 to about 13,000
transcription units, we take 12,000 as a working figure for the number of
protein coding genes in D. melanogaster.
Smyd3 is identified as a novel «histone -
code reader»
protein, which invades active chromatin domains and potentiates the
transcription of cancer - related
genes.
Epigenetic modifications of promoter regions that influence the
transcription of
genes coding for crucial
protein products can be induced by the environment.