In addition, profiling has been exploited to identify non-coding RNAs that may represent downstream targets of activated oncogenic pathways or that are targeting
protein coding genes involved in cancer.
Not exact matches
Some
proteins that these
genes code for are known to be
involved in stress and cell death.
Four HCN
genes that
code for
proteins which form ion channels in neurons could be
involved, because these channels are vital for electrical signalling in nerves.
These
genes code for
proteins involved in transporting small containers called vesicles throughout the healthy cell, but these
proteins are often hijacked by viruses in order to move the virus through the cell.
Many of the additional 38 missing
genes looked like they
coded for
proteins involved in controlling the activity of other
genes.
The new locus they have identified is near a cluster of
genes which
code for
proteins called «glycophorins» that are
involved in the malaria parasite's invasion of red blood cells.
Even more notable, Loki has
genes that
code for
proteins involved in phagocytosis, the process by which one cell can swallow another — and widely believed to be the way eukaryotes acquired mitochondria, a cell's power source.
Some of the
genes involved help regulate the flow of ions in and out of the cells, particularly nerve cells; others
code for so - called heat shock
proteins that are typically induced during stress.
«
Genes code for the sequence of amino acids in proteins, and some are involved in the regulation of the expression of other genes,» he
Genes code for the sequence of amino acids in
proteins, and some are
involved in the regulation of the expression of other
genes,» he
genes,» he says.
As a postdoc in the lab of Zefeng Wang, PhD, a member of the UNC Lineberger Comprehensive Cancer Center, Choudhury stumbled upon DAZAP1 while searching for
proteins involved in alternative splicing — when a single
gene organizes its genetic
code to create different
proteins with various functions.
The Bag1
gene, for example,
codes for a
protein that in humans is
involved in inhibiting an essential natural process called «programmed cell death.»
One of the
genes codes for a
protein that allows neurons to respond to serotonin, a neurotransmitter
involved in mood.
The two groups, they found, had different versions of a crucial
gene, one that
coded for a
protein involved in pigmentation.
Infants with more methylation of a
gene known as retinoid X receptor - α (RXRα), which
codes for a
protein involved in the development of fat cells and fat metabolism, were more likely to be obese at age 9.
The
genes involved code for
proteins that control basic physiological processes such as energy consumption, growth rate, and cell division.
They discovered that earwax type was determined by a change in just one DNA nucleotide in a
gene called ABCC11, which was previously found to
code for a
protein involved in transporting molecules across cell membranes.
«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the
genes»
coding for
proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific
proteins involved in tumor growth.»
TKM - 080301 targets a specific
gene called polo - like kinase 1 (PLK1), which
codes for a
protein involved in tumor cell growth.
Uncovering regulatory
genes involved in the scleractinian biomineralization process and their
coded proteins is truly a challenge because genetic manipulation methods of mutagenesis are not yet accessible in scleractinian corals.
Working within Mitocheck, a European research consortium, Jan has helped exploit sequence knowledge to systematically interrogate all 21,000
protein -
coding genes one after another, identifying which are
involved in cell division.
Mutations for monogenic epilepsies have been found primarily in
genes coding for ion channels 32 as well as in two different
proteins that may be
involved in neurogenesis 33.