In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that
the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.
Not exact matches
The GJB6 gene encodes the
CONNEXIN 30
protein, which is essential in hearing development, and a deficiency of the gene results in the second most common disease among cases of hereditary hearing loss that have no other disease in the inner ear.
Cell transplantation can compensate for missing
CONNEXIN and may improve hearing loss by adding properly functioning
CONNEXIN proteins.
First, the research team succeeded in efficiently inducing inner ear cells expressing inner ear specific
proteins, such as
CONNEXIN 26,
CONNEXIN 30, and PENDRIN, from human iPS cells.
Until recently it was thought that all vertebrate gap junction subunits are
connexins, and invertebrate gap junction
proteins are innexins [1, 2].
Individual
connexin, innexin and pannexin
proteins have all been shown to form gap junction channels with similar properties as assayed in paired Xenopus oocytes (for example, [4, 7, 8]-RRB-.