Sentences with phrase «protein expressing cell»

Negative, intermediate and / or strong protein expressing cell lines cores verified using Quantitative Digital Pathology (QDP)

Defined human cell line cores containing positive and negative protein expressing cell lines on the same slide

Not exact matches

Because the human cells had been genetically engineered to express green fluorescent protein, the tiny blobs showed up in brilliant lime through the transparent window that the scientists glued into the mice's skull.

So, the researchers — headed by Professor of Physics and Biological Sciences Shane Hutson and Associate Professor of Cell and Developmental Biology Andrea Page - McCaw — targeted cells on the back of fruit fly pupae that expressed a protein that fluoresces in the presence of calcium ions.

Immunophenotyping — a laboratory procedure used to study the proteins expressed by cells — is very commonly used in basic science research as well as in laboratory diagnostic testing.

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

Although the gene is only temporarily expressed, this is enough to make proteins that repair the cells for life, he says.

The hair cells also expressed a green protein, showing they had taken up the gene.

Green: the stem cells and their progeny express protein.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

Here they have been infected by a herpes virus that carries a «brainbow cassette,» which makes cells express proteins that are tagged with a variety of fluorescent colors.

Many cells expressing the HIV - 1 Gag protein were detected at the surface of the nasopharyngeal tonsil or adenoid.

There are hundreds of RNA - binding proteins in the human genome that together regulate the processing, turnover and localization of the many thousands of RNA molecules expressed in cells.

«We found that a protein expressed by gut bacteria called Bacteroides works to prevent IBD by rapidly recruiting white blood cells to kill a cell of the immune system that is responsible for orchestrating IBD,» says McCoy.

Thus, signals coming from a given neuron provide information about odors that activate the specific receptor protein expressed by that cell.

CRH, in turn, triggered production of the cell surface protein FasL; trophoblasts expressing FasL then form a protective shield of sorts around the embryo by forcing any attacking immune cells to self - destruct.

The researchers found that aggressive LUAD cells expressed a number of proteins that allow them to persist outside the lungs in small numbers.

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down - regulated in developing neurons by a brain - enriched regulatory RNA called miR - 9.

Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.

«But if you have stem cells that are over expressing this protein TRAF6, they may proliferate longer and they may repair the muscle much more effectively.»

«We have been able to show that this protein is highly expressed in metastatic triple - negative breast cancer, and when we are depleting it from triple - negative breast cancer cells, we found that the cancer cells are not metastasizing,» Dr. Paul said.

«We have shown that it is now possible to accurately design complex, multipass transmembrane proteins that can be expressed in cells.

They found that atypical protein kinase c lambda / iota, which is known to influence cell growth, was highly expressed and phosphorylated in metastatic breast cancers.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

Fibronectin is a protein that is expressed in the space surrounding cells.

So Harkany and his colleagues cultured mouse embryonic brain cells that expressed cannabinoid receptor proteins (CBRs) and exposed them to gradients of synthetic cannabinoids.

To visualize the brain locations of these patches, they engineered the dati lacking mutant cells to express a green fluorescent protein.

This clinical trial sponsored by Juno Therapeutics is testing JCAR017, which targets the CD19 protein expressed on most B - cell leukemias and lymphomas.

However, in some patients, the leukemia recurred without the CD19 target and expressed a protein that the CAR T cells were unable to recognize — CD22.

In PLAT - 02, the CAR T cells are reprogrammed to recognize and target the CD19 protein that is expressed by most precursor B acute lymphoblastic leukemia cells.

These infrared fluorescent proteins are expressed well in mammalian cells and mice, and can be used for whole - body imaging.

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

They compared the global proteome (all of the expressed proteins) of Ras - driven cancer cells where autophagy was present to those where autophagy was deficient.

«There are genes and proteins that are expressed in a cell and their activity, or expression level, changes with time of day,» explained St. John.

When a cell in your body expresses a gene, it produces a specific protein.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

Using animal models, Pickles has already found candidate molecular biomarkers that indicate if the epithelial cells in the tiniest airways are expressing the RSV NS2 protein.

And you need to express the gene in cells or bacteria before you can make large quantities of its protein product.

With the PLAT - 04 trial, researchers will now be able to reprogram CAR T cells to detect and destroy leukemia cells that express the CD22 protein.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

If the miRNA recognition sequence binds to miRNA expressed in the desired cells, the expression of the regulatory protein is suppressed, thus distinguishing the cell type from others that do not contain the miRNA and express the protein.

«But what we've now shown is that RSV has an increased ability to cause airway obstruction because, during an RSV infection, the virus expresses a specific RSV - encoded non-structural protein, or NS2, in epithelial cells, causing the cells to shed from the airway lining and into the airway lumen.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

Because the MS4A proteins are expressed on many cells in the body, the researchers will also test whether they detect cues that are generated by the body itself.

The fact is that one of the key differences between «beige fat», which appears when administering melatonin, and «white fat», is that «beige fat» cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

But rather than delivering the entire gene for the clotting - factor proteins to cells, as most gene therapies do, the researchers used the viruses to engineer immune - regulating B cells to express a fragment of the clotting factor fused to an immune molecule called an immunoglobulin.

One difference that is clear is that exhausted T cells express the programmed cell death protein - 1 (PD - 1), which commands them not to attack normal, healthy cells, but can also prevent them from striking at cancerous or chronically infected cells.

Single - cell mouse embryos were infected in vitro with recombinant lentiviral vectors to generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter.

The group employed various viral tracing methods — infecting receptor - expressing neurons with a virus strain and watching them spread as they label infected cells with a fluorescent protein — to visualize the neural circuit downstream of the ESP1 receptor, as well as providing an image of nerve fibers belonging to specific neurons in the brain and synapses relaying impulses from neuron to neuron, to map the anatomical foundation that conveys ESP1 signals in the brain.