Sentences with phrase «protein homolog»

Thursday, Oct. 20, 9:30 - 9:45 am, Room 221, West Building Platform Presentation: Mutations in spliceosome - associated protein homolog CWC27 cause autosomal recessive syndromic retinitis pigmentosa M. Xu, Baylor College of Medicine, et al

Not exact matches

«This reaction is interesting as close relatives of this protein, known as homologs have also been found in animals — ranging from invertebrates like the horseshoe crab to humans — where they play a role in the defence against bacteria,» continues Künzler.

The researchers conclude that Upd2 is the «functional homolog» of leptin, meaning the protein in flies acts very much like leptin does in people.

No. 5,817,479, entitled Human Kinase Homologs, claims 44 ESTs which are fragments of genes encoding protein kinases.

Analysis of the primary sequence relationships of DMC1 from Saccharomyces cerevisiae and UvsX of T4 relative to the three - dimensional structure of RecA from Escherichia coli suggests that both proteins are structural homologs of bacterial RecA proteins.

The proteins were selected because the same (homolog) proteins exist in the human brain as well.

In a paper published by Scientific Reports today, the research team found the activity of this protein, called PTEN (for Phosphatase and tensin homolog deleted on chromosome 10), is different between men and women.

The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

He investigates the chaperones and heat shock proteins (Hsp) found in yeast and mammalian cells (as well as their Escherichia coli homologs) using structural, biochemical, and cell biological methods.

A Ribosome Assembly Factor Ebp2p, the Yeast Homolog of EBNA1 - Binding Protein 2, Is Involved in the Secretory Response.

Alternate reading frame protein (ARF) complexes with mouse double minute 2 homolog 2 (MDM2), an E3 ubiquitin ligase that regulates the stability of p53 and therefore suppressing tumor growth, it is also involved in the immune response, by modulating the tumor environment [46].

The ovals outside contain the number of CDSs that do not have homologs in any of the strains analyzed; that means unique predicted proteins.

Importantly, the composite genomes of Asgard archaea encode homologs of actin genes, actin - binding proteins, multiple ESCRT complex homologues, and tubulin.

We find homologs in genomes across the eukaryotic tree of life, map known and de novo protein functionalities, and examine co-evolution between proteins and protein motifs.

Abbreviations: AL3E, after L3 ecdysis; FoxO, Forkhead Box O; FRE, FoxO - Response Element; GBP, Growth - Blocking Peptide; GFP, green fluorescent protein; IIS, insulin / insulin - like growth factor signaling; ILP, insulin - like peptide; L3, third larval instar; pAKT, phosphorylated AKT; ppl, pumpless; qPCR, quantitative PCR; Rheb, Ras homolog enriched in brain ortholog; TOR, Target of Rapamycin

We define phylogenetic strata as the deepest node in the branch at which at least one detectable homolog is present, where a detectable homolog is defined as a blastp hit where the alignment covers at least 50 % of the shorter protein with at least 30 % positives.

In addition, DNA sequence analysis of multiple Drosophila and mammalian Boule homologs revealed that, unlike other reproductive proteins [11], [16], [17], Boule evolution has been driven not by positive selection, but by purifying selection.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

While reproductive proteins with conserved homologs in different phyla are not uncommon, most of them are involved in general cellular functions, and are hence also required for other non-reproductive processes [18], [19].

We separately aligned the protein sequences of known Boule homologs among two distant metazoan groups, mammals and insects, and established a consensus sequence for the RNA recognition motif (RRM) in each group (Figure S1).

The identified homologs were verified by BLASTing against the human protein database, which should identify human BOULE as the top hit sequence with highest similarity.

CHICAGO — The protein known as phosphatase and tensin homolog (PTEN) is frequently mutated or affected by cancer as tumors develop.

Osmotic Stress Induces Rapid Activation of a Salicylic Acid - Induced Protein Kinase and a Homolog of Protein Kinase ASK1 in Tobacco Cells

(B) In Trichoplax, the protein with highest sequence similarity to the Boule consensus sequence does not contain the key signature amino acids of Boule and is not a Boule homolog.

Therefore, homologs of a known gametogenic protein — Boule — are present throughout both deuterostomes and protostomes.

Interestingly, the mammalian Boule proteins appeared to share higher sequence similarity than insect homologs despite the fact that mammals have an additional Boule - like protein, Dazl, suggesting that the presence of Dazl did not relieve the selective pressure on Boule in any significant way.

Assembly is critical to HBV replication and is unique to the virus (there are no cellular homologs to capsid protein).

Osmotic stress induces rapid activation of a salicylic acid - induced protein kinase and a homolog of protein kinase ASK1 in tobacco cells.

(A) The yeast protein with highest similarity to the Boule consensus sequence is Hrp1, but it is not a Boule homolog.

XtalPred provides: (1) a detailed comparison of the protein's features to the corresponding distribution from TargetDB; (2) a summary of protein features and predictions that indicate problems that are likely to be encountered during protein crystallization; (3) prediction of ligands; and (4)(optional) lists of close homologs from complete microbial genomes that are more likely to crystallize.

With the discovery of Asgard» clade archaea, the homologs of key eukaryote cytoskeletal proteins have, for the first time, been identified in archaea.

For example, clusters containing genes that are upregulated during the course of ES cell differentiation (Table 3) include in order of time of expression: cluster 30 that represents genes which take part in the formation of the three embryonic germ layers during gastrulation, i.e., Goosecoid, Cerberus like 1 homolog, Wnt3, Mesp1, Mixl1, mEomes and Even - skipped 1; cluster 15 containing molecular regulators of early mesoderm development including Bmp2, Bmp5, Msx1, Msx2, Cripto, Tbx20, Hey2, Smad6, Vegfr2 (Kdr), Foxf1 and Hand1; cluster 20, which comprises regulatory and structural genes linked to hemopoiesis such as Gata1, Nfe2, Klf1, Tie1, hemoglobins (Hba - x, Hbb - b1) and Glycophorin A; cluster 12, which is rich in genes involved in cardiac development, e.g., Mef2c, Myl4, cardiac Troponin T2, Tropomodulin 1, myosin binding protein C, Bves, Angiopoietin 1 and Angiopoietin 2; and, cluster 4, which consists mostly of genes associated with neuronal development and differentiation, for example, Neurog1, Neurog2, Olig2, Nkx6.1, Neurod4, Pou3f2, Pou3f4, Cacna2d3, Cacng4, Kcnq2 and EphA5.

Upon engraftment into the medial prefrontal cortex in rats, the homolog of the human anterior cingulate cortex, the cells assumed neuronal morphologies, expressed monoaminergic - specific proteins, and seemed to functionally integrate, as assessed by the upregulation of the immediate - early gene, cfos.

Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron.

This means that some oocytes might need to keep up their cohesion (between sisters AND homologs) over decades, which, considering the half - life of your average protein, can be challenging.

The insulin receptor signaling cascade is inhibited by several phosphatases, including protein tyrosine phosphatase 1B (PTB 1B), phosphatase and tensin homolog on chromosome 10 (PTEN) and SH2 - domain - containing inositol phosphatase (SHIP2), all of which are inactivated by ROS.