Not exact matches
The mice had symptoms such as abnormal
brain function,
impaired memory and high levels of either amyloid - beta or tau
proteins in the
brain.
The group» finding that the
impaired intracellular
protein trafficking leads to neuropsychiatric disorders - related abnormal higher
brain functions has high impact on the fields of psychiatry, basic medical sciences, and pharmaceutical sciences.
The research group showed that a molecule, ARHGAP33 regulates synaptic
functions and behaviors via intracellular
protein trafficking and that the lack of ARHGAP33 causes neuropsychiatric disorder - related
impaired higher
brain functions.
He founded Gladstone's multi-pronged research program on Alzheimer's in 1998, and has since identified molecular and cellular processes by which amyloid - beta
proteins, which accumulate in the
brains of Alzheimer patients,
impair cognitive
functions.
It can also
impair immune
functioning and may contribute to the development of
protein «plaques» in the
brain, both of which have been linked to Alzheimer's development.