Sentences with phrase «protein isoforms»

His graduate work focused on the molecular mechanisms of DNA replication and protein trafficking in mitochondria, and the translational control of novel mitochondrial protein isoforms.

My lab has generated mouse models to mimic the increase or the decrease of BIN1 protein isoforms in the brain.

We observe that protein isoforms expressed from W01A8.1 are cytoplasmic proteins, residing predominantly on membranous structures of enterocytes and epidermal cells that have the characteristics of lipid droplets.

Since using the WormBase name of W01A8.1 (MDT - 28) would be misleading, the gene is referred here by the cosmid name W01A8.1, which gives rise to at least three protein isoforms designated W01A8.1 a, W01A8.1 b, and W01A8.1 c from at least seven different transcripts (W01A8.1 a. 1, W01A8.1 a. 2, W01A8.1 b. 1, W01A8.1 b. 2, W01A8.1 b. 3, W01A8.1 c. 1, W01A8.1 c. 2).

When the PP2A catalytic C subunit associates with the A and B subunits several protein isoforms, namely holoenzymes, are produced with distinct activity and substrate specificity.

«We found that the protein isoforms expressed in African Americans with prostate cancer do not always respond to targeted therapies, whereas these drugs were found to be effective in European Americans with prostate cancer and do end up killing off the cancer,» said Lee.

The African American mRNA variants encode protein isoforms that make a tumor more aggressive, whereas the protein isoforms generated in European Americans appear to make the tumor less aggressive.

The clearest finding from proteomics experiments is that most human genes have a single main protein isoform, while those alternative isoforms that are identified tend to be the most biologically plausible: those with the most cross-species conservation and those that do not compromise functional domains.

In 60 801 patients with coronary heart disease and 123 504 controls, OR for myocardial infarction was 0 · 96 (0 · 94 - 0 · 98; p < 0 · 0001) per 1 - SD increment in apolipoprotein (a) protein isoform size in serum due to rs2457564, which was directionally concordant with the OR observed in PROMIS for a similar change.

Not exact matches

These varying combinations lead to the generation of slightly different proteins known as isoforms, which can end up functioning differently from each other.

Carstens hopes that further study of Esrp1 and Esrp2, and in particular the proteins whose splice isoforms they control, will uncover useful clues about how these defects arise and how they might be remedied.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

We are one of the most referenced companies in the industry and continue to collaborate to develop products such as isoform - specific AKT antibodies, green fluorescent protein (GFP) and red fluorescent protein (RFP) antibodies, and fluorochrome - conjugated secondary antibodies.

Called isoforms, these proteins are produced when only part of the gene's code is read.

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

The muscles from IL - 15Rα — KO mice had a greater relative expression of the SERCAII isoform and lower mRNA and protein levels of calsequestrin, both characteristic of slow muscles (52).

According to the C. elegans nomenclature, we suggest to rename W01A8.1 as Cel - plin - 1 (isoform a, b, and c) and proteins Cel - PLIN - 1 (isoform a, b, and c).

Novel Isoforms of Heat Shock Transcription Factor 1, HSF1?a and HSF1?ß, Regulate Chaperone Protein Gene Transcription.

Cytosolic splice isoform of Hsp70 nucleotide exchange factor Fes1 is required for the degradation of misfolded proteins in yeast.

Two isoforms of the cold - inducible mRNA - binding protein RBM3 localize to dendrites and promote translation.

To investigate cellular response, we have the ability to measure mRNA levels, splice isoforms, protein levels, and post-translation modifications.

Subcellular targeting of nine calcium - dependent protein kinase isoforms from Arabidopsis.

Endoplasmic reticulum - resident heat shock protein 90 (HSP90) isoform glucose - regulated protein 94 (GRP94) regulates cell polarity and cancer cell migration by affecting intracellular transport.

Isoform - dependent effects of apoE on doublecortin - positive cells and microtubule - associated protein 2 immunoreactivity following 137 Cs irradiation.

ABP is a protein closely related to GRIP and exists in two isoforms with 6 and 7 PDZ domains, respectively.

Each of these proteins possess several isoforms with characteristics that either mimic or antagonize the role of p53.

Both mRNA detection and protein detection was negative for all isoforms of p73.